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Progranulin Regulates Inflammation and Tumor
- Source :
- Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
- Publication Year :
- 2020
- Publisher :
- Bentham Science Publishers Ltd., 2020.
-
Abstract
- Progranulin (PGRN) mediates cell cycle progression and cell motility as a pleiotropic growth factor and acts as a universal regulator of cell growth, migration and transformation, cell cycle, wound healing, tumorigenesis, and cytotoxic drug resistance as a secreted glycoprotein. PGRN overexpression can induce the secretion of many inflammatory cytokines, such as IL-8, -6,-10, TNF-α. At the same time, this protein can promote tumor proliferation and the occurrence and development of many related diseases such as gastric cancer, breast cancer, cervical cancer, colorectal cancer, renal injury, neurodegeneration, neuroinflammatory, human atherosclerotic plaque, hepatocarcinoma, acute kidney injury, amyotrophic lateral sclerosis, Alzheimer’s disease and Parkinson’s disease. In short, PGRN plays a very critical role in injury repair and tumorigenesis, it provides a new direction for succeeding research and serves as a target for clinical diagnosis and treatment, thus warranting further investigation. Here, we discuss the potential therapeutic utility and the effect of PGRN on the relationship between inflammation and cancer.
- Subjects :
- tumor
Carcinogenesis
Colorectal cancer
Immunology
Inflammation
cell motility
medicine.disease_cause
Article
Proinflammatory cytokine
03 medical and health sciences
Progranulins
0302 clinical medicine
Cell Movement
Neoplasms
progranulin
medicine
Animals
Humans
Immunology and Allergy
Cell Proliferation
030304 developmental biology
Pharmacology
0303 health sciences
business.industry
Cell growth
Cell Cycle
Neurodegeneration
pleiotropic growth factor
Cancer
Neurodegenerative Diseases
General Medicine
Cell cycle
medicine.disease
Cell Transformation, Neoplastic
030220 oncology & carcinogenesis
Cancer research
Cytokines
medicine.symptom
business
Subjects
Details
- ISSN :
- 18715230
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....5a92ba9004826eff0dc94f975be54054