Back to Search
Start Over
The janus face of NKT cell function in autoimmunity and infectious diseases
- Source :
- International Journal of Molecular Sciences, Vol 19, Iss 2, p 440 (2018), International Journal of Molecular Sciences
- Publication Year :
- 2018
- Publisher :
- MDPI AG, 2018.
-
Abstract
- Natural killer T cells (NKT) are a subset of T lymphocytes bridging innate and adaptive immunity. These cells recognize self and microbial glycolipids bound to non-polymorphic and highly conserved CD1d molecules. Three NKT cell subsets, type I, II and NKT-like expressing different antigen receptors (TCR) were described and TCR activation promotes intracellular events leading to specific functional activities. NKT can exhibit different functions depending on the secretion of soluble molecules and the interaction with other cell types. NKT cells act as regulatory cells in the defence against infections but, on the other hand, their effector functions can be involved in the pathogenesis of several inflammatory disorders due to their exposure to different microbial or self antigens, respectively. A deep understanding of the biology and functions of type I, II and NKT-like cells as well as their interplay with cell types acting in innate (Neuthrophils, Innate Lymphoid cells, Machrophages and Dendritic cells) and adaptive immunity (CD4+,CD8+ and Double Negative T cells) should be important to design potential immunotherapies for infectious and autoimmune diseases.
- Subjects :
- 0301 basic medicine
glycolipids
Autoimmunity
Review
Adaptive Immunity
medicine.disease_cause
Catalysi
immunology
lcsh:Chemistry
0302 clinical medicine
T-Lymphocyte Subsets
lcsh:QH301-705.5
Spectroscopy
Innate lymphoid cell
hemic and immune systems
Computer Science Applications1707 Computer Vision and Pattern Recognition
General Medicine
NKT
Natural killer T cell
Acquired immune system
Computer Science Applications
Cell biology
CD1D
microbes
Cell type
chemical and pharmacologic phenomena
Glycolipid
Biology
CD1d
Communicable Diseases
Catalysis
Inorganic Chemistry
03 medical and health sciences
medicine
Animals
Humans
Microbe
Physical and Theoretical Chemistry
Molecular Biology
Inflammation
T-cell receptor
Organic Chemistry
Models, Immunological
Alpha-galactosylceramide
Glycolipids
Microbes
Sulfatide
Immunity, Innate
Settore MED/16 - Reumatologia
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
biology.protein
Natural Killer T-Cells
CD8
030215 immunology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences, Vol 19, Iss 2, p 440 (2018), International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....5a988d62da1ba70dbcfff785b1fa4af3