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Imaging of normal lung, liver and parotid gland function for radiotherapy
Imaging of normal lung, liver and parotid gland function for radiotherapy
- Source :
- Partridge, M, Yamamoto, T, Grau, C, Høyer, M & Muren, L 2010, ' Imaging of normal lung, liver and parotid gland function for radiotherapy ', Acta Oncologica, vol. 49, no. 7, pp. 997-1011 . https://doi.org/10.3109/0284186X.2010.504735
- Publication Year :
- 2010
- Publisher :
- Informa UK Limited, 2010.
-
Abstract
- There is growing clinical evidence that functional imaging is useful for target volume definition and early assessment of tumour response to external beam radiotherapy. A subject that has perhaps received less attention, but is no less promising, is the application of functional imaging to the prediction or measurement of radiation adverse effects in normal tissues. In this manuscript, we review the current published literature describing the use of positron emission tomography (PET), four-dimensional computed tomography (4D-CT), single photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI) to study normal tissue function in the context of radiotherapy to the lung, liver and head & neck. Published results to date demonstrate that functional imaging can be used to preferentially avoid normal tissues not easily identifiable on solely anatomical images. It is also a potentially very powerful tool for the early detection of radiotherapy-induced normal tissue adverse effects and could provide valuable data for building predictive models of outcome. However, one of the major challenges to building useful predictive models is that, to date, there are very little data available with combined images of normal function, 3D delivered radiation dose and clinical outcomes. Prospective data collection through well-constructed studies which use established morbidity scores is clearly a priority if significant progress is to be made in this area.
- Subjects :
- Diagnostic Imaging
medicine.medical_specialty
Radiography
medicine.medical_treatment
Single-photon emission computed tomography
Models, Biological
medicine
Humans
Parotid Gland
Computer Simulation
Radiology, Nuclear Medicine and imaging
External beam radiotherapy
Radiation Injuries
Radionuclide Imaging
Lung
Radiotherapy
medicine.diagnostic_test
business.industry
Radiotherapy Planning, Computer-Assisted
Magnetic resonance imaging
Hematology
General Medicine
Radiation therapy
Functional imaging
Liver
Oncology
Positron emission tomography
Radiology
business
Nuclear medicine
Preclinical imaging
Subjects
Details
- ISSN :
- 1651226X and 0284186X
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Acta Oncologica
- Accession number :
- edsair.doi.dedup.....5aaa85a21a578a2723aa8ccec98b68df
- Full Text :
- https://doi.org/10.3109/0284186x.2010.504735