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Post-ischemic treatment with toki-shakuyaku-san (tang-gui-shao-yao-san) prevents the impairment of spatial memory induced by repeated cerebral ischemia in rats
- Source :
- The American journal of Chinese medicine. 33(3)
- Publication Year :
- 2005
-
Abstract
- Previously we have reported that Toki-shakuyaku-san (TSS) ameliorated the impairment of spatial memory induced by single cerebral ischemia (1 × 10 minutes) and scopolamine, a muscarinic receptor antagonist. In this experiment, we studied the effect of TSS on repeated cerebral ischemia (2 × 10 minutes, 1-hour interval) induced impairment of spatial memory and neuronal injury in rats. The 8-day post-ischemic treatment with TSS (30-300 mg/kg) was administered p.o. once per day. TSS dose-dependently prevented the impairment of spatial memory, neuronal death and TUNEL positive cells induced by repeated cerebral ischemia. In order to determine the mechanism of TSS, we also studied the effect of TSS on GluR2 mRNA, one of the glutamate ?-amino-3- hydroxy-5-methyl-4-isoxazole (AMPA) receptor subunits. Repeated cerebral ischemia significantly decreased GluR2 flop mRNA at 1 and 3 days after the occlusion. TSS (300 mg/kg) significantly suppressed the decrease in GluR2 flop at 3 days after repeated cerebral ischemia. These results suggested that the TSS has neuroprotective action which may be indirectly mediated by the AMPA receptor, and TSS may be beneficial for the treatment of cerebrovascular dementia. © 2005 World Scientific Publishing Company. Institute for Advanced Research in Asian Science and Medicine.
- Subjects :
- Male
genetic structures
Paeonia
Brain Ischemia
Chinese drug
medicinal plant
Muscarinic acetylcholine receptor
rank sum test
Spatial memory impairment
rat
AMPA receptor
rat strain
toki shakuyaku san
Receptor
Angelica
Neurons
TUNEL assay
Cell Death
messenger RNA
Porfia cocos extract
article
Glutamate receptor
Atractylodes lancea
memory disorder
General Medicine
Cerebral ischemia
spatial memory
unclassified drug
multiinfarct dementia
Neuroprotective Agents
cnidium officinale extract
Alisma orientale extract
Anesthesia
plant extract
Alisma
neuroprotection
tang gui shao yao san
medicine.medical_specialty
Neuronal death
animal experiment
nick end labeling
Ischemia
Cnidium
Neuroprotection
animal tissue
Paeonia lactiflora
reverse transcription polymerase chain reaction
Student t test
Internal medicine
cnidium officinale
medicine
Animals
maze test
RNA, Messenger
Receptors, AMPA
Rats, Wistar
Alisma orientale
Maze Learning
nerve cell lesion
Paeonia lactiflora extract
nonhuman
Dose-Response Relationship, Drug
nerve cell necrosis
business.industry
animal model
angelica acutiloba
Antagonist
Atractylodes
Atractylodes extract
Angelica acutiloba extract
bacterial infections and mycoses
medicine.disease
Rats
Disease Models, Animal
Endocrinology
Toki-shakuyaku-san
Complementary and alternative medicine
receptor subunit
business
Porfia cocos
Drugs, Chinese Herbal
Subjects
Details
- ISSN :
- 0192415X
- Volume :
- 33
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The American journal of Chinese medicine
- Accession number :
- edsair.doi.dedup.....5ac48905c5fca4bfc5b03b59db72838c