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Cerebrosides and 2-pyridone alkaloids from the halotolerant fungus Penicillium chrysogenum grown in a hypersaline medium
- Source :
- Journal of natural products. 74(5)
- Publication Year :
- 2011
-
Abstract
- Five new cerebrosides, chrysogesides A-E (1-5), and two new 2-pyridone alkaloids, chrysogedones A and B (6 and 7), were isolated from the fermentation broth of Penicillium chrysogenum PXP-55, a halotolerant fungus grown in a hypersaline medium. Among them, chrysogesides B-D (2-4) are the first cerebrosides that contain an unsaturated C(19)-fatty acid. Their structures were identified by spectroscopic and chemical methods, including CD spectroscopy as well as the modified Mosher's method. Compound 2 showed antimicrobial activity against Enterobacter aerogenes with an MIC value of 1.72 μM.
- Subjects :
- Salinity
Stereochemistry
Pharmaceutical Science
Fungus
Microbial Sensitivity Tests
Biology
Penicillium chrysogenum
Enterobacter aerogenes
Analytical Chemistry
Alkaloids
Cerebrosides
Drug Discovery
Pharmacology
Molecular Structure
Organic Chemistry
Fungi imperfecti
biology.organism_classification
Antimicrobial
Cerebroside
Anti-Bacterial Agents
Complementary and alternative medicine
Biochemistry
Halotolerance
Molecular Medicine
Bacteria
Subjects
Details
- ISSN :
- 15206025
- Volume :
- 74
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of natural products
- Accession number :
- edsair.doi.dedup.....5ac67d798dba44a2123d1515460babe4