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Lipoprotein(a): A Promising Marker for Residual Cardiovascular Risk Assessment
- Source :
- Disease Markers, Vol 35, Iss 5, Pp 551-559 (2013), Disease markers
- Publication Year :
- 2013
- Publisher :
- Hindawi Limited, 2013.
-
Abstract
- Atherosclerotic cardiovascular diseases (CVD) are still the leading cause of morbidity and mortality worldwide, although optimal medical therapy has been prescribed for primary and secondary preventions. Residual cardiovascular risk for some population groups is still considerably high although target low density lipoprotein-cholesterol (LDL-C) level has been achieved. During the past few decades, compelling pieces of evidence from clinical trials and meta-analyses consistently illustrate that lipoprotein(a) (Lp(a)) is a significant risk factor for atherosclerosis and CVD due to its proatherogenic and prothrombotic features. However, the lack of effective medication for Lp(a) reduction significantly hampers randomized, prospective, and controlled trials conducting. Based on previous findings, for patients with LDL-C in normal range, Lp(a) may be a useful marker for identifying and evaluating the residual cardiovascular risk, and aggressively lowering LDL-C level than current guidelines’ recommendation may be reasonable for patients with particularly high Lp(a) level.
- Subjects :
- medicine.medical_specialty
Clinical Biochemistry
Population
Coronary Artery Disease
Review Article
Risk Assessment
chemistry.chemical_compound
Internal medicine
Genetics
medicine
Secondary Preventions
Humans
Significant risk
education
Molecular Biology
education.field_of_study
lcsh:R5-920
biology
Cholesterol
business.industry
Biochemistry (medical)
Cholesterol, LDL
General Medicine
Lipoprotein(a)
Clinical trial
Endocrinology
chemistry
biology.protein
Risk assessment
business
lcsh:Medicine (General)
Biomarkers
Lipoprotein
Subjects
Details
- Language :
- English
- ISSN :
- 18758630 and 02780240
- Volume :
- 35
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Disease Markers
- Accession number :
- edsair.doi.dedup.....5ac7cf834d2c1e2f8d0ec68130846d70