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Could intramuscular storage of dietary nitrate contribute to its ergogenic effect? A mini-review
- Source :
- Free Radical Biology and Medicine. 152:295-300
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Extensive research performed over the past 10 years has resulted in dietary nitrate being considered a nutritional supplement that can improve exercise performance. However, there is still limited insight in the metabolic fate of dietary nitrate following the appearance of nitrate and nitrite in the circulation. Recent observations in humans suggest the storage of nitrate in skeletal muscle tissue. This short review discusses the possibility of nitrate being stored and utilized in human skeletal muscle tissue, and why confirming this may increase our understanding of how the nitrate -nitrite -NO pathway improves exercise performance. Further insight in skeletal muscle nitrate storage and metabolism may provide answers to current gaps in knowledge, such as the ergogenic benefit of acute vs multiday dietary nitrate supplementation, as well as the suggested muscle fiber -type specific effects on exercise performance. In this mini -review, specific questions that need further exploration are also discussed.
- Subjects :
- XANTHINE-OXIDASE
0301 basic medicine
BEETROOT JUICE
Nitrite
Physiology
Performance-Enhancing Substances
Ergogenic aid
Beetroot Juice
Biochemistry
SUPPLEMENTATION
Mini review
Nitric oxide
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Double-Blind Method
Nitrate
Physiology (medical)
Dietary Nitrate
Exercise performance
Skeletal Muscle Tissue
medicine
Humans
EXERCISE PERFORMANCE
Muscle, Skeletal
Exercise
Nitrites
Nitrates
NITRIC-OXIDE
business.industry
Skeletal muscle
HUMAN SKELETAL-MUSCLE
REDUCTION
030104 developmental biology
medicine.anatomical_structure
chemistry
OXYGEN COST
Dietary Supplements
MODERATE-INTENSITY
INORGANIC NITRATE
Beta vulgaris
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 08915849
- Volume :
- 152
- Database :
- OpenAIRE
- Journal :
- Free Radical Biology and Medicine
- Accession number :
- edsair.doi.dedup.....5ad985de2cfc533a6377a7f444d1aa06
- Full Text :
- https://doi.org/10.1016/j.freeradbiomed.2020.03.025