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The large spectrum of Spitzoid tumors: a retrospective survival study
- Source :
- Giornale Italiano di Dermatologia e Venereologia. 154
- Publication Year :
- 2019
- Publisher :
- Edizioni Minerva Medica, 2019.
-
Abstract
- Background There is no universally-accepted classification of Spitzoid tumors. This makes it difficult to assign a correct diagnosis and select a treatment that minimizes the risk of overestimating, or worse, underestimating, the malignant potential of these tumors. The aim of this study was to describe the clinical-pathological and epidemiological features of Spitzoid tumors, as well as to assess mortality in these patients. Methods This retrospective cohort study looked at data on Spitzoid tumors excised in 1999-2012 at the Dermatologic Clinic of the Turin University Hospital. Spitzoid melanoma specific survival curves were generated with the Kaplan-Meier method and compared using the log-rank test. Results In this time period, 1663 lesion were described at the pathologic report as Spitzoid. 262 (15.75%) were Spitz nevi, 307 (18.46%) Reed nevi, 827 (49.73%), 810 (48.71%) Spitzoid dysplastic nevi, 17(1.02%) atypical Spitzoid tumors, and 267 (16.06%) Spitzoid melanomas. Median follow-up time was 9 years. Out of the entire cohort only 24 patients died from melanoma. All of them received a diagnosis of Spitzoid melanoma. None of the patients with a diagnosis of not melanoma Spitz tumor died for melanoma during the follow-up. Conclusions In the large majority of the cases, Spitz tumor should be considered as benign lesion and excised only if melanoma features are seen. The used clinical pathological classification avoid misdiagnoses, inappropriate treatment and the risk of death for melanoma.
- Subjects :
- Adult
Male
medicine.medical_specialty
Skin Neoplasms
Survival
Adolescent
epithelioid and spindle cell
Kaplan-Meier Estimate
Dermatology
Cohort Studies
Young Adult
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Nevus, Epithelioid and Spindle Cell
Neoplasms
Epidemiology
medicine
Humans
Nevus
Child
Melanoma
neoplasms
Pathological
Survival rate
Retrospective Studies
business.industry
Retrospective cohort study
Middle Aged
medicine.disease
Survival Rate
Cohort
Nevus, epithelioid and spindle cell
Dysplastic Nevus Syndrome
Female
Follow-Up Studies
business
Cohort study
Subjects
Details
- ISSN :
- 18271820 and 03920488
- Volume :
- 154
- Database :
- OpenAIRE
- Journal :
- Giornale Italiano di Dermatologia e Venereologia
- Accession number :
- edsair.doi.dedup.....5ae1d687bf14f66e37795a9b76681b5d