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Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus
- Source :
- Bioorganic & Medicinal Chemistry Letters. 21:1716-1718
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited Staphylococcus aureus enoyl-ACP reductase with an IC(50) of 6 μM and also showed antibacterial activity against S. aureus and MRSA.
- Subjects :
- Spectrometry, Mass, Electrospray Ionization
Magnetic Resonance Spectroscopy
Spectrophotometry, Infrared
Clinical Biochemistry
Catechols
Pharmaceutical Science
Pharmacognosy
Reductase
medicine.disease_cause
Biochemistry
Microbiology
Inhibitory Concentration 50
chemistry.chemical_compound
Drug Discovery
medicine
Enzyme Inhibitors
Molecular Biology
Antibacterial agent
chemistry.chemical_classification
biology
Organic Chemistry
Fungi
biology.organism_classification
Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)
Enzyme
chemistry
Phellinus linteus
Pyrones
Staphylococcus aureus
Hispidin
Molecular Medicine
Antibacterial activity
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....5b01d63be814171ec298133f68011b15
- Full Text :
- https://doi.org/10.1016/j.bmcl.2011.01.080