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Brain Atrophy in Healthy Aging Is Related to CSF Levels of Aβ1-42
- Source :
- Cerebral Cortex. 20:2069-2079
- Publication Year :
- 2010
- Publisher :
- Oxford University Press (OUP), 2010.
-
Abstract
- Reduced levels of beta-amyloid(1-42) (Abeta1-42) and increased levels of tau proteins in the cerebrospinal fluid (CSF) are found in Alzheimer's disease (AD), likely reflecting Abeta deposition in plaques and neuronal and axonal damage. It is not known whether these biomarkers are associated with brain atrophy also in healthy aging. We tested the relationship between CSF levels of Abeta1-42 and tau (total tau and tau phosphorylated at threonine 181) proteins and 1-year brain atrophy in 71 cognitively normal elderly individuals. Results showed that under a certain threshold value, levels of Abeta1-42 correlated highly with 1-year change in a wide range of brain areas. The strongest relationships were not found in the regions most vulnerable early in AD. Above the threshold level, Abeta1-42 was not related to brain changes, but significant volume reductions as well as ventricular expansion were still seen. It is concluded that Abeta1-42 correlates with brain atrophy and ventricular expansion in a subgroup of cognitively normal elderly individuals but that reductions independent of CSF levels of Abeta1-42 is common. Further research and follow-up examinations over several years are needed to test whether degenerative pathology will eventually develop in the group of cognitively normal elderly individuals with low levels of Abeta1-42.
- Subjects :
- Male
Aging
medicine.medical_specialty
Pathology
Amyloid
Cognitive Neuroscience
Disease
Brain mapping
Cerebral Ventricles
Cellular and Molecular Neuroscience
Cerebrospinal fluid
Atrophy
Internal medicine
mental disorders
medicine
Humans
Aged
Aged, 80 and over
Cerebral atrophy
Brain Mapping
Amyloid beta-Peptides
Brain
Articles
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Peptide Fragments
medicine.anatomical_structure
Endocrinology
nervous system
Cerebral cortex
Disease Progression
Female
Psychology
Alzheimer's Disease Neuroimaging Initiative
Subjects
Details
- ISSN :
- 14602199 and 10473211
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Cerebral Cortex
- Accession number :
- edsair.doi.dedup.....5b02ed80c832d73eda565a7fe5504426