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Pre-Clinical Investigation of Keratose as an Excipient of Drug Coated Balloons
- Source :
- Molecules, Volume 25, Issue 7, Molecules, Vol 25, Iss 1596, p 1596 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI, 2020.
-
Abstract
- Background: Drug-coated balloons (DCBs), which deliver anti-proliferative drugs with the aid of excipients, have emerged as a new endovascular therapy for the treatment of peripheral arterial disease. In this study, we evaluated the use of keratose (KOS) as a novel DCB-coating excipient to deliver and retain paclitaxel. Methods: A custom coating method was developed to deposit KOS and paclitaxel on uncoated angioplasty balloons. The retention of the KOS-paclitaxel coating, in comparison to a commercially available DCB, was evaluated using a novel vascular-motion simulating ex vivo flow model at 1 h and 3 days. Additionally, the locoregional biological response of the KOS-paclitaxel coating was evaluated in a rabbit ilio-femoral injury model at 14 days. Results: The KOS coating exhibited greater retention of the paclitaxel at 3 days under pulsatile conditions with vascular motion as compared to the commercially available DCB (14.89 &plusmn<br />4.12 ng/mg vs. 0.60 &plusmn<br />0.26 ng/mg, p = 0.018). Histological analysis of the KOS&ndash<br />paclitaxel-treated arteries demonstrated a significant reduction in neointimal thickness as compared to the uncoated balloons, KOS-only balloon and paclitaxel-only balloon. Conclusions: The ability to enhance drug delivery and retention in targeted arterial segments can ultimately improve clinical peripheral endovascular outcomes.
- Subjects :
- Pulsatile flow
Drug Evaluation, Preclinical
Pharmaceutical Science
02 engineering and technology
030204 cardiovascular system & hematology
Balloon
Analytical Chemistry
chemistry.chemical_compound
0302 clinical medicine
Drug Delivery Systems
Coating
Coated Materials, Biocompatible
Drug Discovery
Drug Carriers
Keratose
021001 nanoscience & nanotechnology
Immunohistochemistry
Paclitaxel
Chemistry (miscellaneous)
Drug delivery
Molecular Medicine
endovascular
0210 nano-technology
medicine.drug
Drug coated balloon
pre-clinical
drug-coated balloon
Excipient
Antineoplastic Agents
engineering.material
Article
lcsh:QD241-441
03 medical and health sciences
Peripheral Arterial Disease
lcsh:Organic chemistry
medicine
Animals
Physical and Theoretical Chemistry
business.industry
Organic Chemistry
Cardiovascular Agents
Keratosis
chemistry
drug delivery
engineering
business
Ex vivo
Angioplasty, Balloon
Biomedical engineering
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 25
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....5b0e7277f2c0f190a46af263d31b51b9