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Low-dose lacosamide-induced atrial fibrillation: Case analysis with literature review
Low-dose lacosamide-induced atrial fibrillation: Case analysis with literature review
- Source :
- Epilepsy & Behavior Case Reports
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Lacosamide (LCM) is a novel antiepileptic drug (AED) approved by the FDA for adjunctive treatment of partial epilepsy with and without secondary generalization. Lacosamide dose-dependent dysrhythmias (PR-interval prolongation, AV block, and atrial fibrillation/flutter) have been reported. This case represents the first instance of LCM-induced atrial fibrillation following a low loading dose (200mg). Risk factors for atrial fibrillation are addressed and discussed in the context of this case. Full cardiac history is recommended prior to patients being initiated on LCM. Cardiac monitoring may be required for at-risk patients on LCM. Clinicians need to be cognizant of this potential adverse effect.
- Subjects :
- medicine.medical_specialty
Lacosamide
medicine.medical_treatment
Case Report
Context (language use)
Video-EEG
Pharmacology
Loading dose
Education
Behavioral Neuroscience
Epilepsy
Cardiac adverse events
Internal medicine
medicine
Adverse effect
business.industry
Atrial fibrillation
equipment and supplies
medicine.disease
Low dose
Complex partial status epilepticus
Neurology
Adjunctive treatment
cardiovascular system
Cardiology
sense organs
Neurology (clinical)
Cardiac monitoring
business
medicine.drug
Subjects
Details
- ISSN :
- 22133232
- Volume :
- 1
- Database :
- OpenAIRE
- Journal :
- Epilepsy & Behavior Case Reports
- Accession number :
- edsair.doi.dedup.....5b23a52e70f69bc8cd89a11cfce02444
- Full Text :
- https://doi.org/10.1016/j.ebcr.2012.10.006