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Low-dose lacosamide-induced atrial fibrillation: Case analysis with literature review

Low-dose lacosamide-induced atrial fibrillation: Case analysis with literature review

Authors :
Ram Mani
Kenneth R. Kaufman
Arnaldo E. Velez
Stephen Wong
Source :
Epilepsy & Behavior Case Reports
Publication Year :
2013
Publisher :
Elsevier BV, 2013.

Abstract

Lacosamide (LCM) is a novel antiepileptic drug (AED) approved by the FDA for adjunctive treatment of partial epilepsy with and without secondary generalization. Lacosamide dose-dependent dysrhythmias (PR-interval prolongation, AV block, and atrial fibrillation/flutter) have been reported. This case represents the first instance of LCM-induced atrial fibrillation following a low loading dose (200mg). Risk factors for atrial fibrillation are addressed and discussed in the context of this case. Full cardiac history is recommended prior to patients being initiated on LCM. Cardiac monitoring may be required for at-risk patients on LCM. Clinicians need to be cognizant of this potential adverse effect.

Details

ISSN :
22133232
Volume :
1
Database :
OpenAIRE
Journal :
Epilepsy & Behavior Case Reports
Accession number :
edsair.doi.dedup.....5b23a52e70f69bc8cd89a11cfce02444
Full Text :
https://doi.org/10.1016/j.ebcr.2012.10.006