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Large-scale association analyses identify host factors influencing human gut microbiome composition
- Source :
- Nature Genetics, 53, 2, pp. 156-165, Kurilshikov, A, Medina-Gomez, C, Bacigalupe, R, Radjabzadeh, D, Wang, J, Demirkan, A, le Roy, C I, Raygoza Garay, J A, Finnicum, C T, Liu, X, Zhernakova, D V, Bonder, M J, Hansen, T H, Frost, F, Rühlemann, M C, Turpin, W, Moon, J-Y, Kim, H-N, Lüll, K, Barkan, E, Shah, S A, Fornage, M, Szopinska-Tokov, J, Wallen, Z D, Borisevich, D, Agreus, L, Andreasson, A, Bang, C, Bedrani, L, Bell, J T, Bisgaard, H, Boehnke, M, Boomsma, D I, Burk, R D, Claringbould, A, Croitoru, K, Davies, G E, van Duijn, C M, Duijts, L, Falony, G, Fu, J, van der Graaf, A, Hansen, T, Homuth, G, Hughes, D A, Ijzerman, R G, Jackson, M A, Jaddoe, V W V, Joossens, M, Jørgensen, T, Keszthelyi, D, Knight, R, Laakso, M, Laudes, M, Launer, L J, Lieb, W, Lusis, A J, Masclee, A A M, Moll, H A, Mujagic, Z, Qibin, Q, Rothschild, D, Shin, H, Sørensen, S R J, Steves, C J, Thorsen, J, Timpson, N J, Tito, R Y, Vieira-Silva, S, Völker, U, Völzke, H, Võsa, U, Wade, K H, Walter, S, Watanabe, K, Weiss, S, Weiss, F U, Weissbrod, O, Westra, H-J, Willemsen, G, Payami, H, Jonkers, D M A E, Arias Vasquez, A, de Geus, E J C, Meyer, K A, Stokholm, J, Segal, E, Org, E, Wijmenga, C, Kim, H-L, Kaplan, R C, Spector, T D, Uitterlinden, A G, Rivadeneira, F, Franke, A, Lerch, M M, Franke, L, Sanna, S, D’Amato, M, Pedersen, O, Paterson, A D, Kraaij, R, Raes, J & Zhernakova, A 2021, ' Large-scale association analyses identify host factors influencing human gut microbiome composition ', Nature Genetics, vol. 53, no. 2, pp. 156-165 . https://doi.org/10.1038/s41588-020-00763-1, Nature Genetics, 53(2), 156-165. Nature Publishing Group, Nat Genet, Kurilshikov, A, Medina-Gomez, C, Bacigalupe, R, Radjabzadeh, D, Wang, J, Demirkan, A, Le Roy, C I, Raygoza Garay, J A, Finnicum, C T, Liu, X, Zhernakova, D V, Bonder, M J, Hansen, T H, Frost, F, Rühlemann, M C, Turpin, W, Moon, J Y, Kim, H N, Lüll, K, Barkan, E, Shah, S A, Fornage, M, Szopinska-Tokov, J, Wallen, Z D, Borisevich, D, Agreus, L, Andreasson, A, Bang, C, Bedrani, L, Bell, J T, Bisgaard, H, Boehnke, M, Boomsma, D I, Burk, R D, Claringbould, A, Croitoru, K, Davies, G E, van Duijn, C M, Duijts, L, Falony, G, Fu, J, van der Graaf, A, Hansen, T, Homuth, G, Hughes, D A, Ijzerman, R G, Jackson, M A, Jaddoe, V W V, Joossens, M, Jørgensen, T, Keszthelyi, D, Knight, R, Laakso, M, Laudes, M, Launer, L J, Lieb, W, Lusis, A J, Masclee, A A M, Moll, H A, Mujagic, Z, Qibin, Q, Rothschild, D, Shin, H, Sørensen, S J, Steves, C J, Thorsen, J, Timpson, N J, Tito, R Y, Vieira-Silva, S, Völker, U, Völzke, H, Võsa, U, Wade, K H, Walter, S, Watanabe, K, Weiss, S, Weiss, F U, Weissbrod, O, Westra, H J, Willemsen, G, Payami, H, Jonkers, D M A E, Arias Vasquez, A, de Geus, E J C, Meyer, K A, Stokholm, J, Segal, E, Org, E, Wijmenga, C, Kim, H L, Kaplan, R C, Spector, T D, Uitterlinden, A G, Rivadeneira, F, Franke, A, Lerch, M M, Franke, L, Sanna, S, D’Amato, M, Pedersen, O, Paterson, A D, Kraaij, R, Raes, J, Zhernakova, A & MiBioGen Consortium Initiative 2021, ' Large-scale association analyses identify host factors influencing human gut microbiome composition ', Nature Genetics, vol. 53, no. 2, pp. 156-165 . https://doi.org/10.1038/s41588-020-00763-1, Nature Genetics, Nature Genetics, 53, 156-165, Kurilshikov, A, Medina-Gomez, C, Bacigalupe, R, Radjabzadeh, D, Wang, J, Demirkan, A, Le Roy, C I, Raygoza Garay, J A, Finnicum, C T, Liu, X, Zhernakova, D V, Bonder, M J, Hansen, T H, Frost, F, Rühlemann, M C, Turpin, W, Moon, J Y, Kim, H N, Lüll, K, Barkan, E, Shah, S A, Fornage, M, Szopinska-Tokov, J, Wallen, Z D, Borisevich, D, Agreus, L, Andreasson, A, Bang, C, Bedrani, L, Bell, J T, Bisgaard, H, Boehnke, M, Boomsma, D I, Burk, R D, Claringbould, A, Croitoru, K, Davies, G E, van Duijn, C M, Duijts, L, Falony, G, Fu, J, van der Graaf, A, Hansen, T, Homuth, G, Hughes, D A, Ijzerman, R G, Jackson, M A, Jaddoe, V W V, Joossens, M, Jørgensen, T, Keszthelyi, D, Knight, R, Laakso, M, Laudes, M, Launer, L J, Lieb, W, Lusis, A J, Masclee, A A M, Moll, H A, Mujagic, Z, Qibin, Q, Rothschild, D, Shin, H, Sørensen, S J, Steves, C J, Thorsen, J, Timpson, N J, Tito, R Y, Vieira-Silva, S, Völker, U, Völzke, H, Võsa, U, Wade, K H, Walter, S, Watanabe, K, Weiss, S, Weiss, F U, Weissbrod, O, Westra, H J, Willemsen, G, Payami, H, Jonkers, D M A E, Arias Vasquez, A, de Geus, E J C, Meyer, K A, Stokholm, J, Segal, E, Org, E, Wijmenga, C, Kim, H L, Kaplan, R C, Spector, T D, Uitterlinden, A G, Rivadeneira, F, Franke, A, Lerch, M M, Franke, L, Sanna, S, D’Amato, M, Pedersen, O, Paterson, A D, Kraaij, R, Raes, J & Zhernakova, A 2021, ' Large-scale association analyses identify host factors influencing human gut microbiome composition ', Nature Genetics, vol. 53, pp. 156-165 . https://doi.org/10.1038/s41588-020-00763-1, Nature genetics, vol 53, iss 2, Nature Genetics, 53, 156-165. Nature Publishing Group, Kurilshikov, A, Hughes, D A, Timpson, N J, Wade, K H, Zhernakova, A & et al. 2021, ' Large-scale association analyses identify host factors influencing human gut microbiome composition ', Nature Genetics, vol. 53, no. 2, pp. 156-165 . https://doi.org/10.1038/s41588-020-00763-1
- Publication Year :
- 2021
-
Abstract
- Contains fulltext : 231681.pdf (Publisher’s version ) (Closed access) To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 individuals (24 cohorts). Microbial composition showed high variability across cohorts: only 9 of 410 genera were detected in more than 95% of samples. A genome-wide association study of host genetic variation regarding microbial taxa identified 31 loci affecting the microbiome at a genome-wide significant (P
- Subjects :
- Male
Linkage disequilibrium
Genome-wide association study
Genome-wide association studies
Medical and Health Sciences
Oral and gastrointestinal
Linkage Disequilibrium
Cohort Studies
0302 clinical medicine
RNA, Ribosomal, 16S
2.1 Biological and endogenous factors
Aetiology
Child
Lactase
Genetics & Heredity
2. Zero hunger
Genetics
0303 health sciences
Biological Sciences
Child, Preschool
MENDELIAN RANDOMIZATION
Female
Life Sciences & Biomedicine
Biotechnology
Adult
16S
Adolescent
Quantitative Trait Loci
Locus (genetics)
Biology
Quantitative trait locus
GENOTYPE IMPUTATION
Microbiology
metagenome
Article
diseases
03 medical and health sciences
Clinical Research
Genetic variation
Mendelian randomization
Humans
Microbiome
Preschool
Nutrition
030304 developmental biology
Ribosomal
ecosystem
ENVIRONMENT
Science & Technology
Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]
IDENTIFICATION
Human Genome
Genetic Variation
Mendelian Randomization Analysis
FRAMEWORK
Gastrointestinal Microbiome
Metabolism
Metagenomics
genome-wide association
RNA
Bifidobacterium
Digestive Diseases
030217 neurology & neurosurgery
Developmental Biology
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 10614036
- Database :
- OpenAIRE
- Journal :
- Nature Genetics, 53, 2, pp. 156-165, Kurilshikov, A, Medina-Gomez, C, Bacigalupe, R, Radjabzadeh, D, Wang, J, Demirkan, A, le Roy, C I, Raygoza Garay, J A, Finnicum, C T, Liu, X, Zhernakova, D V, Bonder, M J, Hansen, T H, Frost, F, Rühlemann, M C, Turpin, W, Moon, J-Y, Kim, H-N, Lüll, K, Barkan, E, Shah, S A, Fornage, M, Szopinska-Tokov, J, Wallen, Z D, Borisevich, D, Agreus, L, Andreasson, A, Bang, C, Bedrani, L, Bell, J T, Bisgaard, H, Boehnke, M, Boomsma, D I, Burk, R D, Claringbould, A, Croitoru, K, Davies, G E, van Duijn, C M, Duijts, L, Falony, G, Fu, J, van der Graaf, A, Hansen, T, Homuth, G, Hughes, D A, Ijzerman, R G, Jackson, M A, Jaddoe, V W V, Joossens, M, Jørgensen, T, Keszthelyi, D, Knight, R, Laakso, M, Laudes, M, Launer, L J, Lieb, W, Lusis, A J, Masclee, A A M, Moll, H A, Mujagic, Z, Qibin, Q, Rothschild, D, Shin, H, Sørensen, S R J, Steves, C J, Thorsen, J, Timpson, N J, Tito, R Y, Vieira-Silva, S, Völker, U, Völzke, H, Võsa, U, Wade, K H, Walter, S, Watanabe, K, Weiss, S, Weiss, F U, Weissbrod, O, Westra, H-J, Willemsen, G, Payami, H, Jonkers, D M A E, Arias Vasquez, A, de Geus, E J C, Meyer, K A, Stokholm, J, Segal, E, Org, E, Wijmenga, C, Kim, H-L, Kaplan, R C, Spector, T D, Uitterlinden, A G, Rivadeneira, F, Franke, A, Lerch, M M, Franke, L, Sanna, S, D’Amato, M, Pedersen, O, Paterson, A D, Kraaij, R, Raes, J & Zhernakova, A 2021, ' Large-scale association analyses identify host factors influencing human gut microbiome composition ', Nature Genetics, vol. 53, no. 2, pp. 156-165 . https://doi.org/10.1038/s41588-020-00763-1, Nature Genetics, 53(2), 156-165. Nature Publishing Group, Nat Genet, Kurilshikov, A, Medina-Gomez, C, Bacigalupe, R, Radjabzadeh, D, Wang, J, Demirkan, A, Le Roy, C I, Raygoza Garay, J A, Finnicum, C T, Liu, X, Zhernakova, D V, Bonder, M J, Hansen, T H, Frost, F, Rühlemann, M C, Turpin, W, Moon, J Y, Kim, H N, Lüll, K, Barkan, E, Shah, S A, Fornage, M, Szopinska-Tokov, J, Wallen, Z D, Borisevich, D, Agreus, L, Andreasson, A, Bang, C, Bedrani, L, Bell, J T, Bisgaard, H, Boehnke, M, Boomsma, D I, Burk, R D, Claringbould, A, Croitoru, K, Davies, G E, van Duijn, C M, Duijts, L, Falony, G, Fu, J, van der Graaf, A, Hansen, T, Homuth, G, Hughes, D A, Ijzerman, R G, Jackson, M A, Jaddoe, V W V, Joossens, M, Jørgensen, T, Keszthelyi, D, Knight, R, Laakso, M, Laudes, M, Launer, L J, Lieb, W, Lusis, A J, Masclee, A A M, Moll, H A, Mujagic, Z, Qibin, Q, Rothschild, D, Shin, H, Sørensen, S J, Steves, C J, Thorsen, J, Timpson, N J, Tito, R Y, Vieira-Silva, S, Völker, U, Völzke, H, Võsa, U, Wade, K H, Walter, S, Watanabe, K, Weiss, S, Weiss, F U, Weissbrod, O, Westra, H J, Willemsen, G, Payami, H, Jonkers, D M A E, Arias Vasquez, A, de Geus, E J C, Meyer, K A, Stokholm, J, Segal, E, Org, E, Wijmenga, C, Kim, H L, Kaplan, R C, Spector, T D, Uitterlinden, A G, Rivadeneira, F, Franke, A, Lerch, M M, Franke, L, Sanna, S, D’Amato, M, Pedersen, O, Paterson, A D, Kraaij, R, Raes, J, Zhernakova, A & MiBioGen Consortium Initiative 2021, ' Large-scale association analyses identify host factors influencing human gut microbiome composition ', Nature Genetics, vol. 53, no. 2, pp. 156-165 . https://doi.org/10.1038/s41588-020-00763-1, Nature Genetics, Nature Genetics, 53, 156-165, Kurilshikov, A, Medina-Gomez, C, Bacigalupe, R, Radjabzadeh, D, Wang, J, Demirkan, A, Le Roy, C I, Raygoza Garay, J A, Finnicum, C T, Liu, X, Zhernakova, D V, Bonder, M J, Hansen, T H, Frost, F, Rühlemann, M C, Turpin, W, Moon, J Y, Kim, H N, Lüll, K, Barkan, E, Shah, S A, Fornage, M, Szopinska-Tokov, J, Wallen, Z D, Borisevich, D, Agreus, L, Andreasson, A, Bang, C, Bedrani, L, Bell, J T, Bisgaard, H, Boehnke, M, Boomsma, D I, Burk, R D, Claringbould, A, Croitoru, K, Davies, G E, van Duijn, C M, Duijts, L, Falony, G, Fu, J, van der Graaf, A, Hansen, T, Homuth, G, Hughes, D A, Ijzerman, R G, Jackson, M A, Jaddoe, V W V, Joossens, M, Jørgensen, T, Keszthelyi, D, Knight, R, Laakso, M, Laudes, M, Launer, L J, Lieb, W, Lusis, A J, Masclee, A A M, Moll, H A, Mujagic, Z, Qibin, Q, Rothschild, D, Shin, H, Sørensen, S J, Steves, C J, Thorsen, J, Timpson, N J, Tito, R Y, Vieira-Silva, S, Völker, U, Völzke, H, Võsa, U, Wade, K H, Walter, S, Watanabe, K, Weiss, S, Weiss, F U, Weissbrod, O, Westra, H J, Willemsen, G, Payami, H, Jonkers, D M A E, Arias Vasquez, A, de Geus, E J C, Meyer, K A, Stokholm, J, Segal, E, Org, E, Wijmenga, C, Kim, H L, Kaplan, R C, Spector, T D, Uitterlinden, A G, Rivadeneira, F, Franke, A, Lerch, M M, Franke, L, Sanna, S, D’Amato, M, Pedersen, O, Paterson, A D, Kraaij, R, Raes, J & Zhernakova, A 2021, ' Large-scale association analyses identify host factors influencing human gut microbiome composition ', Nature Genetics, vol. 53, pp. 156-165 . https://doi.org/10.1038/s41588-020-00763-1, Nature genetics, vol 53, iss 2, Nature Genetics, 53, 156-165. Nature Publishing Group, Kurilshikov, A, Hughes, D A, Timpson, N J, Wade, K H, Zhernakova, A & et al. 2021, ' Large-scale association analyses identify host factors influencing human gut microbiome composition ', Nature Genetics, vol. 53, no. 2, pp. 156-165 . https://doi.org/10.1038/s41588-020-00763-1
- Accession number :
- edsair.doi.dedup.....5b2e8f48d9f4a1a7f6864962650bb03d