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Effects of Dietary Arginine and Glutamine on Alleviating the Impairment Induced by Deoxynivalenol Stress and Immune Relevant Cytokines in Growing Pigs
- Source :
- PLoS ONE, Vol 8, Iss 7, p e69502 (2013), PLoS ONE
- Publication Year :
- 2013
- Publisher :
- Public Library of Science (PLoS), 2013.
-
Abstract
- Deoxynivalenol (DON) is a mycotoxin that reduces feed intake and animal performance, especially in swine. Arginine and glutamine play important roles in swine nutrition. The objective of this study was to determine the effects of dietary supplementation with arginine and glutamine on both the impairment induced by DON stress and immune relevant cytokines in growing pigs. A total of forty 60-d-old healthy growing pigs with a mean body weight of 16.28±1.54 kg were randomly divided into 5 groups, and assigned to 3 amino acid treatments fed 1.0% arginine (Arg), 1.0% glutamine (Gln) and 0.5% Arg+0.5% Gln, respectively, plus a toxin control and a non-toxin control. Pigs in the 3 amino acid treatments were fed the corresponding amino acids, and those in non-toxin control and toxin control were fed commercial diet with 1.64% Alanine as isonitrogenous control for 7 days. The toxin control and amino acid treatments were then challenged by feeding DON-contaminated diet with a final DON concentration of 6 mg/kg of diet for 21 days. No significant differences were observed between toxin control and the amino acid groups with regard to the average daily gain (ADG), although the values for average daily feed intake (ADFI) in the amino acid groups were significantly higher than that in toxin control (P
- Subjects :
- Anatomy and Physiology
Animal Nutrition
Arginine
Swine
Glutamine
lcsh:Medicine
medicine.disease_cause
Immune Physiology
Amino Acids
Insulin-Like Growth Factor I
lcsh:Science
Animal Management
Alanine
chemistry.chemical_classification
Gastrointestinal tract
Multidisciplinary
Agriculture
Amino acid
Chemistry
Organic Acids
Biochemistry
Medicine
Cytokines
Tumor necrosis factor alpha
Research Article
medicine.medical_specialty
Immunology
Biology
Agricultural Production
Immune system
Internal medicine
medicine
Animals
Nutrition
Tumor Necrosis Factor-alpha
Toxin
Organic Chemistry
Body Weight
lcsh:R
Endocrinology
chemistry
Immune System
Growth Hormone
Dietary Supplements
Interleukin-2
Clinical Immunology
Veterinary Science
lcsh:Q
Trichothecenes
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....5b44995fc5d171f7c172540ab5d3db66
- Full Text :
- https://doi.org/10.1371/journal.pone.0069502