Back to Search
Start Over
Lateralized Contributions of Medial Prefrontal Cortex Network to Episodic Memory Deficits in Subjects With Amnestic Mild Cognitive Impairment
- Source :
- Frontiers in Aging Neuroscience, Vol 13 (2021), Frontiers in Aging Neuroscience
- Publication Year :
- 2021
- Publisher :
- Frontiers Media SA, 2021.
-
Abstract
- Both episodic memory and executive function are impaired in amnestic mild cognitive impairment (aMCI) subjects, but it is unclear if these impairments are independent or interactive. The present study aimed to explore the relationship between episodic memory deficits and executive function deficits, and the underlying functional mechanisms in aMCI subjects. Thirty-one aMCI subjects and 27 healthy subjects underwent neuropsychological tests and multimodal magnetic resonance imaging (MRI) scans. Hippocampal networks and medial prefrontal cortex (MPFC) networks were identified based on resting-sate functional MRI (fMRI) data. AMCI subjects displayed lower episodic memory scores and executive function scores than control subjects, and the episodic memory scores were positively correlated with the executive function scores in aMCI subjects. Brain network analyses showed an interaction between the hippocampal networks and the MPFC networks, and the interaction was significantly associated with the episodic memory scores and the executive function scores. Notably, aMCI subjects displayed higher functional connectivity (FC) of the right hippocampal network with the right prefrontal cortex than did control subjects, but this difference disappeared when controlling for the MPFC networks. Furthermore, the effects of the MPFC networks on the hippocampal networks were significantly associated with the episodic memory scores in aMCI subjects. The present findings suggested that the episodic memory deficits in aMCI subjects could be partially underpinned by the modulation of the MPFC networks on the hippocampal networks.
- Subjects :
- Aging
medicine.medical_specialty
Cognitive Neuroscience
Neurosciences. Biological psychiatry. Neuropsychiatry
Audiology
Hippocampal formation
behavioral disciplines and activities
mild cognitive impairment
mental disorders
hippocampal network
medicine
Cognitive impairment
Prefrontal cortex
Episodic memory
Original Research
medicine.diagnostic_test
Aging Neuroscience
Neuropsychology
Healthy subjects
medial prefrontal cortex network
Magnetic resonance imaging
episodic memory
functional magnetic resonance imaging
executive function
Psychology
Functional magnetic resonance imaging
RC321-571
Subjects
Details
- ISSN :
- 16634365
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Frontiers in Aging Neuroscience
- Accession number :
- edsair.doi.dedup.....5b56cbf2b29be7bf99c50a398449d10d