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Contrast-Enhanced Mammography for Screening Women after Breast Conserving Surgery
Contrast-Enhanced Mammography for Screening Women after Breast Conserving Surgery
- Source :
- Cancers, Vol 12, Iss 3495, p 3495 (2020), Cancers, Volume 12, Issue 12
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Simple Summary Breast cancer survivors are at risk for recurrence, and the early detection of recurrence improves survival. Therefore, imaging surveillance is performed for women who have breast-conserving surgery. The aim of our retrospective study was to compare routine mammography with contrast-enhanced mammography in the screening (asymptomatic) post-treatment setting. We confirmed that when screening women with breast conservation surgery, contrast-enhanced mammography had a higher cancer detection rate (15.4/1000) and positive predictive value of biopsies (42.9%) than full-field digital mammography (6.2/1000 and 37.5%, respectively). Abstract To investigate the value of contrast-enhanced mammography (CEM) compared to full-field digital mammography (FFDM) in screening breast cancer patients after breast-conserving surgery (BCS), this Health Insurance Portability and Accountability Act-compliant, institutional review board-approved retrospective, single-institution study included 971 CEM exams in 541 asymptomatic patients treated with BCS who underwent screening CEM between January 2013 and November 2018. Histopathology, or at least a one-year follow-up, was used as the standard of reference. Twenty-one of 541 patients (3.9%) were diagnosed with ipsi- or contralateral breast cancer: six (28.6%) cancers were seen with low-energy images (equivalent to FFDM), an additional nine (42.9%) cancers were detected only on iodine (contrast-enhanced) images, and six interval cancers were identified within 365 days of a negative screening CEM. Of the 10 ipsilateral cancers detected on CEM, four were detected on low-energy images (40%). Of the five contralateral cancers detected on CEM, two were detected on low-energy images (40%). Overall, the cancer detection rate (CDR) for CEM was 15.4/1000 (15/971), and the positive predictive value (PPV3) of the biopsies performed was 42.9% (15/35). For findings seen on low-energy images, with or without contrast, the CDR was 6.2/1000 (6/971), and the PPV3 of the biopsies performed was 37.5% (6/16). In the post-BCS screening setting, CEM has a higher CDR than FFDM.
- Subjects :
- contrast enhanced mammography
Cancer Research
medicine.medical_specialty
Digital mammography
medicine.medical_treatment
Asymptomatic
lcsh:RC254-282
Article
030218 nuclear medicine & medical imaging
breast conserving surgery
03 medical and health sciences
Breast cancer screening
0302 clinical medicine
Health insurance
medicine
Breast-conserving surgery
Mammography
breast conservation
medicine.diagnostic_test
business.industry
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
breast cancer screening
Breast cancer recurrence
Breast conservation
Breast conserving surgery
Contrast enhanced mammography
breast cancer recurrence
Oncology
030220 oncology & carcinogenesis
Histopathology
Screening breast cancer
Radiology
medicine.symptom
business
Subjects
Details
- Language :
- English
- ISSN :
- 20726694
- Volume :
- 12
- Issue :
- 3495
- Database :
- OpenAIRE
- Journal :
- Cancers
- Accession number :
- edsair.doi.dedup.....5b5ffdb265a95f9f089a3b0d41aeef89