Back to Search
Start Over
Relationship between albuminuric CKD and diabetic retinopathy in a real-world setting of type 2 diabetes: Findings from No blind study
- Publication Year :
- 2019
-
Abstract
- Background and aims: Recently, the albuminocentric view of diabetic kidney disease (DKD) in type 2 diabetes (T2DM) has been changing. Therefore, the relationship between diabetic retinopathy (DR) and chronic kidney disease (CKD) has to be addressed according to this new clinical presentation of DKD. The aim of this study was to evaluate, in a real-world setting, the correlation DR–DKD in T2DM. Methods and results: A total of 2068 type 2 diabetic patients enrolled in a multicenter cross-sectional study were investigated. Albuminuric subjects were largely prevalent among subjects with DR (p = 0.019). In the whole study population, no difference in albumin excretion rate (AER) was observed between presence/absence of DR; instead, AER was significantly higher among patients with glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 (CKD) (p = 0.009), above all in those with CKD and AER ≥0.03 g/24 h (p = 0.005). Multivariate analysis confirmed that eGFR (O.R. 0.976; 95% C.I.: 0.960–1.028; p < 0.001) and AER (O.R. 1.249; 95% C.I. 1.001–1.619; p = 0.004) were independently associated with DR and HDL–cholesterol (O.R.: 1.042; 95% C.I.: 1.011–1.120; p = 0.014). Additionally, among patients with eGFR
- Subjects :
- Male
medicine.medical_specialty
endocrine system diseases
Endocrinology, Diabetes and Metabolism
Albumin excretion rate
Medicine (miscellaneous)
Renal function
030209 endocrinology & metabolism
Disease
Type 2 diabetes
030204 cardiovascular system & hematology
Kidney
Severity of Illness Index
03 medical and health sciences
0302 clinical medicine
Blind study
Risk Factors
Internal medicine
medicine
Humans
Albuminuria
Diabetic Nephropathies
Diabetic kidney disease
Renal Insufficiency, Chronic
Aged
Cross-Sectional Studie
Nutrition and Dietetics
Diabetic Retinopathy
business.industry
Risk Factor
Diabetic retinopathy
Middle Aged
medicine.disease
Glomerular filtration rate
Renal Elimination
Cross-Sectional Studies
Diabetes Mellitus, Type 2
Italy
Diabetic Nephropathie
Population study
Female
Cardiology and Cardiovascular Medicine
business
Kidney disease
Human
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....5b71c2f0d893cf5eeca7cfdf8245e395