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Severe growth hormone deficiency and empty sella in obesity: a cross-sectional study
- Publication Year :
- 2015
- Publisher :
- P. Michael Conn, 2015.
-
Abstract
- Obesity is associated with blunted growth hormone (GH) secretion. In some individuals, hypothalamic–pituitary (HP) structural lesions may contribute to GH deficiency (GHD). We explored pituitary morphology in obese patients with suspected GHD and its association with cardiovascular risk factors, body composition, and cardiac morphology. One hundred and eighty-four adults obese patients with symptoms and signs of GHD (147 females and 37 males; mean age 46.31 ± 12.11 years), out of 906 consecutive white obese outpatients, were evaluated. The main measures were anthropometric data, blood pressure, lipid profile, glycemic parameters, pituitary hormones, and insulin-like growth factor-1 values, echocardiography, magnetic resonance imaging (MRI) of the HP region, body composition, and growth hormone-releasing hormone plus arginine test. Seventy patients had GHD (GH peak values
- Subjects :
- Adult
Male
growth hormone deficiency
medicine.medical_specialty
Adolescent
Endocrinology, Diabetes and Metabolism
Comorbidity
Severity of Illness Index
Growth hormone deficiency
Young Adult
Magnetic resonance imaging
Endocrinology
Diabetes mellitus
Internal medicine
medicine
Humans
Pituitary
Empty sella
Obesity
Child
Bone mineral
medicine.diagnostic_test
business.industry
Human Growth Hormone
Empty Sella Syndrome
Settore MED/13 - ENDOCRINOLOGIA
Middle Aged
medicine.disease
Blood pressure
Cross-Sectional Studies
Female
business
Lipid profile
Body mass index
Hormone
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....5b969fb36242f94c29c5fe8165b59367