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Elevated Lactate Dehydrogenase (LDH) level as an independent risk factor for the severity and mortality of COVID-19
- Source :
- Aging (Albany NY)
- Publication Year :
- 2020
-
Abstract
- Early identification of severe patients with coronavirus disease 2019 (COVID-19) is very important for individual treatment. We included 203 patients with COVID-19 by propensity score matching in this retrospective, case-control study. The effects of serum lactate dehydrogenase (LDH) at admission on patients with COVID-19 were evaluated. We found that serum LDH levels had a 58.7% sensitivity and 82.0% specificity, based on a best cut-off of 277.00 U/L, for predicting severe COVID-19. And a cut-off of 359.50 U/L of the serum LDH levels resulted in a 93.8% sensitivity, 88.2% specificity for predicting death of COVID-19. Additionally, logistic regression analysis and Cox proportional hazards model respectively indicated that elevated LDH level was an independent risk factor for the severity (HR: 2.73, 95% CI: 1.25-5.97; P=0.012) and mortality (HR: 40.50, 95% CI: 3.65-449.28; P=0.003) of COVID-19. Therefore, elevated LDH level at admission is an independent risk factor for the severity and mortality of COVID-19. LDH can assist in the early evaluating of COVID-19. Clinicians should pay attention to the serum LDH level at admission for patients with COVID-19.
- Subjects :
- Male
Aging
medicine.medical_specialty
China
Pneumonia, Viral
severity
Logistic regression
Gastroenterology
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
chemistry.chemical_compound
Betacoronavirus
Risk Factors
Internal medicine
Lactate dehydrogenase
Severity of illness
medicine
Humans
Risk factor
Lactate Dehydrogenases
Pandemics
Retrospective Studies
Proportional hazards model
business.industry
Diagnostic Tests, Routine
SARS-CoV-2
Patient Selection
Case-control study
COVID-19
Reproducibility of Results
Retrospective cohort study
lactate dehydrogenase
Cell Biology
Middle Aged
mortality
Early Diagnosis
chemistry
risk factor
Case-Control Studies
Propensity score matching
Female
business
Coronavirus Infections
Research Paper
Subjects
Details
- ISSN :
- 19454589
- Volume :
- 12
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- Aging
- Accession number :
- edsair.doi.dedup.....5bb167d4357d1048a110f0368e374c2b