Supplementary Figures 1 - 2 from Next-Generation Sequencing of Stage IV Squamous Cell Lung Cancers Reveals an Association of PI3K Aberrations and Evidence of Clonal Heterogeneity in Patients with Brain Metastases

Supplementary Figure 1. Copy number pattern in paired lung cancer primaries and brain metastases from patients PP1, PP2, and PP4. Red, blue, and white indicate gain, loss, neutral states, respectively. The total number of shared cytobands (percent shared) between the primary and brain metastases are indicated at the bottom. Supplementary Figure 2A. Genome-wide copy number profile of the PP1 brain metastasis (A) and lung primary (B). Total log-copy ratio (logR) in the tumor versus normal and minor allele frequency (MAF) in the tumor are plotted. Yellow line represents joint segmentation of logR and MAF. Supplementary Figure 2B. Genome-wide copy number profile of the PP4 brain metastasis (A) and lung primary (B). Supplementary Figure 2C. Genome-wide copy number profile of the PP2 brain metastasis (A) and lung primary (B). Pooled normal was used to generate the logR plot. Supplementary Figure 2D. Genome-wide copy number profile of the PP3 brain metastasis (A) and PP5 brain metastasis (B).