Back to Search
Start Over
Analysis of Over 10,000 Cases Finds No Association between Previously Reported Candidate Polymorphisms and Ovarian Cancer Outcome
- Source :
- Cancer Epidemiology Biomarkers & Prevention; Vol 22, Cancer Epidemiology Biomarkers & Prevention
- Publication Year :
- 2013
- Publisher :
- AMER ASSOC CANCER RESEARCH, 2013.
-
Abstract
- Background: Ovarian cancer is a leading cause of cancer-related death among women. In an effort to understand contributors to disease outcome, we evaluated single-nucleotide polymorphisms (SNP) previously associated with ovarian cancer recurrence or survival, specifically in angiogenesis, inflammation, mitosis, and drug disposition genes. Methods: Twenty-seven SNPs in VHL, HGF, IL18, PRKACB, ABCB1, CYP2C8, ERCC2, and ERCC1 previously associated with ovarian cancer outcome were genotyped in 10,084 invasive cases from 28 studies from the Ovarian Cancer Association Consortium with over 37,000-observed person-years and 4,478 deaths. Cox proportional hazards models were used to examine the association between candidate SNPs and ovarian cancer recurrence or survival with and without adjustment for key covariates. Results: We observed no association between genotype and ovarian cancer recurrence or survival for any of the SNPs examined. Conclusions: These results refute prior associations between these SNPs and ovarian cancer outcome and underscore the importance of maximally powered genetic association studies. Impact: These variants should not be used in prognostic models. Alternate approaches to uncovering inherited prognostic factors, if they exist, are needed. Cancer Epidemiol Biomarkers Prev; 22(5); 987–. ©2013 AACR.
- Subjects :
- Oncology
medicine.medical_specialty
Genotype
Epidemiology
Single-nucleotide polymorphism
Polymorphism, Single Nucleotide
Article
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
SNP
Humans
Genetic Predisposition to Disease
Survival analysis
Genetic Association Studies
030304 developmental biology
Genetic association
Proportional Hazards Models
Ovarian Neoplasms
0303 health sciences
Polymorphism, Genetic
Proportional hazards model
business.industry
Cancer
medicine.disease
Prognosis
Survival Analysis
3. Good health
030220 oncology & carcinogenesis
Immunology
Female
business
Ovarian cancer
Subjects
Details
- Language :
- English
- ISSN :
- 10559965
- Volume :
- 22
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Cancer Epidemiology Biomarkers & Prevention
- Accession number :
- edsair.doi.dedup.....5bb7b9c9d21ae855bc189310937237c5
- Full Text :
- https://doi.org/10.1158/1055-9965.EPI-13-0028