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2-Aryloxymethylmorpholine histamine H(3) antagonists
- Source :
- Bioorganicmedicinal chemistry letters. 18(21)
- Publication Year :
- 2008
-
Abstract
- The synthesis and biological activity of a new series of 2-aryloxymethylmorpholine histamine H 3 antagonists is described. The new compounds are high affinity histamine H 3 ligands that penetrate the CNS and occupy the histamine H 3 receptor in rat brain.
- Subjects :
- Histamine N-methyltransferase
Morpholines
Organic Chemistry
Clinical Biochemistry
Pharmaceutical Science
Brain
Biological activity
Histamine H1 receptor
Pharmacology
Biochemistry
Rats
chemistry.chemical_compound
Histamine receptor
chemistry
Histamine H2 receptor
Drug Discovery
Molecular Medicine
Animals
Histamine H4 receptor
Histamine H3 receptor
Molecular Biology
Histamine
Histamine H3 Antagonists
Subjects
Details
- ISSN :
- 14643405
- Volume :
- 18
- Issue :
- 21
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....5bd19ccd5a4b70ad5040aaa25493538d