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Oxidative Damages to Eye Stem Cells, in Response to, Bright and Ultraviolet Light, Their Associated Mechanisms, and Salvage Pathways
- Source :
- Molecular biotechnology. 61(2)
- Publication Year :
- 2018
-
Abstract
- The surface of the eye is continuously exposed to the harshness of the external environment. As a homeostatic mechanism for replenishing the worn off cells of the ocular surface, a balance is maintained via the role of ocular stem cells. However, under extreme conditions of harshness like exposure to bright and ultraviolet light, the ocular stem cells are unable to do the repair mechanisms resulting in severe impairment of vision and disturbances in the eye. This work reappraises the recent understandings of mechanisms of oxidative damages caused to the ocular stem cells by UV/bright light and their probable mitigation.
- Subjects :
- 0106 biological sciences
Cell signaling
genetic structures
Ultraviolet Rays
Bioengineering
Apoptosis
Oxidative phosphorylation
Eye
01 natural sciences
Applied Microbiology and Biotechnology
Biochemistry
Oxidative damage
03 medical and health sciences
Homeostatic mechanism
010608 biotechnology
Ultraviolet light
Medicine
Animals
Humans
Molecular Biology
030304 developmental biology
0303 health sciences
business.industry
Stem Cells
Epithelial Cells
eye diseases
Cell biology
Oxidative Stress
sense organs
Stem cell
business
Ocular surface
Bright light
Biotechnology
Signal Transduction
Stem Cell Transplantation
Subjects
Details
- ISSN :
- 15590305
- Volume :
- 61
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Molecular biotechnology
- Accession number :
- edsair.doi.dedup.....5bd26bab97d11c34d130b9172e56bdbe