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miR-429 functions as a tumor suppressor by targeting FSCN1 in gastric cancer cells
- Source :
- OncoTargets and therapy
- Publication Year :
- 2016
- Publisher :
- Informa UK Limited, 2016.
-
Abstract
- Min Zhang,1 Bing-bin Dong,2 Min Lu,1 Mei-juan Zheng,1 He Chen,1 Jing-zhen Ding,3 A-Man Xu,2 Yuan-hong Xu11Clinical Laboratory, 2Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China; 3Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA, USAAbstract: It has been previously reported that the deregulation of microRNAs in gastric cancer (GC) was correlated with the progression and prognosis. miR-429, a member of the miR-200 family, was previously shown to play an important role in human carcinomas. Our study shows that miR-429 is significantly downregulated in GC tissues compared with matched nontumor tissues. Overexpression of miR-429 in GC cells suppressed cell proliferation. Fascin-1 (FSCN1) was identified as one of the targets of miR-429 and knockdown of FSCN1 mimics the function of miR-429 overexpression. In conclusion, miR-429 acts as a tumor suppressor by targeting FSCN1, suggesting that miR-429 and FSCN1 can both be potential therapeutic targets of GC.Keywords: miR-429, gastric cancer, FSCN1, proliferation
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
proliferation
Biology
OncoTargets and Therapy
law.invention
03 medical and health sciences
0302 clinical medicine
law
microRNA
medicine
Pharmacology (medical)
Original Research
Gene knockdown
Cell growth
miR-429
gastric cancer
Cancer
medicine.disease
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Cancer cell
Cancer research
Suppressor
Function (biology)
FSCN1
Subjects
Details
- ISSN :
- 11786930
- Database :
- OpenAIRE
- Journal :
- OncoTargets and Therapy
- Accession number :
- edsair.doi.dedup.....5bfcb270a4763cb9f6dfb09744fcc290