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Complete Remission of Locally Advanced Penile Squamous Cell Carcinoma after Multimodality Treatment
- Source :
- Rare Tumors
- Publication Year :
- 2016
- Publisher :
- PAGEPress Publications, Pavia, Italy, 2016.
-
Abstract
- Treatment of locally advanced penile squamous cell carcinoma (pSCC) remains highly controversial secondary to disease rarity and lack of prospective randomized controlled trials. The current mainstays of care are multi-modality treatment with neoadjuvant chemotherapy and surgery. However, clinicians often have difficulty making recommendations for patients unable to tolerate chemotherapy or surgery due to scarcity of data to guide clinical decision-making. We report two cases of locally advanced pSCC that achieved complete remission after treatment with cisplatin-based neoadjuvant chemotherapy and surgery in one case, and concurrent cisplatin chemoradiation in a second, supporting the use of chemotherapy as part of first-line multimodal therapy. We also discuss additional treatment options for patients unable to tolerate traditional chemotherapy regimens.
- Subjects :
- Oncology
medicine.medical_specialty
Histology
Penile squamous cell carcinoma
medicine.medical_treatment
030232 urology & nephrology
Locally advanced
Case Report
Disease
Neoadjuvant chemotherapy
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Internal medicine
medicine
Cisplatin
Chemotherapy
business.industry
Multimodality Treatment
Multimodal therapy
Chemoradiation
030220 oncology & carcinogenesis
Surgery
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20363613 and 20363605
- Volume :
- 8
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Rare Tumors
- Accession number :
- edsair.doi.dedup.....5c0d700cc799c8a2a4a3cb9b15b47554