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Role of eotaxin-1/CCL11 in sepsis-induced myocardial injury in elderly patients
- Source :
- Aging (Albany NY)
- Publication Year :
- 2020
- Publisher :
- Impact Journals, LLC, 2020.
-
Abstract
- Myocardial injury is a serious complication of sepsis. The present study aimed to identify potential biomarkers of sepsis-induced myocardial injury. Differentially expressed genes (DEGs) in patients and mice with sepsis-induced myocardial injury were identified via bioinformatic analysis. The identified DEG was tested in elderly patients with sepsis-induced myocardial injury. We identified 19 co-expressed DEGs. The most significant DEG was eotaxin-1/CCL11. We enrolled 25 controls without infections and 28 patients with sepsis-induced myocardial injury. Six of patients died within 30 days. Circulating eotaxin-1/CCL11 levels were significantly higher in patients with sepsis-induced myocardial injury than controls and were higher in non-survivors than survivors (both P < 0.01). Eotaxin-1/CCL11 was positively correlated with troponin I (r=0.48, P=0.01), B-type natriuretic peptide (BNP, r=0.44, P=0.02), and white blood cell (WBC) count (r=0.41, P=0.03). For the prediction of 30-day mortality, eotaxin-1/CCL11 had the greatest discriminatory ability (AUC 0.97) compared with troponin I (AUC 0.89), BNP (AUC 0.80), and WBC count (AUC 0.86). Taken together, eotaxin-1/CCL11 was upregulated in sepsis-injured myocardium and circulating eotaxin-1/CCL11 was a biomarker for predicting severity and mortality of elderly patients with sepsis-induced myocardial injury. These results suggest that eotaxin-1/CCL11 may become a useful biomarkers and potential therapeutic target for sepsis-induced myocardial injury.
- Subjects :
- Chemokine CCL11
Male
Eotaxin
Aging
medicine.medical_specialty
medicine.drug_class
Gastroenterology
sepsis
Sepsis
Leukocyte Count
White blood cell
Internal medicine
Natriuretic Peptide, Brain
Troponin I
Natriuretic peptide
Humans
Medicine
eotaxin-1
CCL11
Aged
Aged, 80 and over
business.industry
Cell Biology
respiratory system
Prognosis
medicine.disease
Survival Rate
medicine.anatomical_structure
septic cardiomyopathy
biomarker
Biomarker (medicine)
Female
Cardiomyopathies
business
Complication
Biomarkers
Research Paper
Subjects
Details
- ISSN :
- 19454589
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Aging
- Accession number :
- edsair.doi.dedup.....5c0ed5bc95abf86db0d75b73f7d6282e