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The predictive value of cytogenetic diagnosis after CVS: 1500 cases
- Source :
- Prenatal diagnosis. 10(2)
- Publication Year :
- 1990
-
Abstract
- The cytogenetic results of 1500 chorionic villus samples (CVS) are presented. In these 1500 samples, 23 samples (1.5 per cent) could not be provided with a diagnosis because of laboratory failure. This failure rate dropped from 3 per cent in the first 500 samples to 0.2 per cent in the last 500. In the remaining 1477 samples, 58 (3.9 per cent) chromosomal aberrations were found. Of these, 21 (36 per cent) proved not to represent the karyotype of the fetus proper. Predictive values of (different groups of) chromosomal aberrations in CVS are calculated. The impact of (differences between) the predictive value for some major chromosomal aberrations is discussed. A tissue- and chromosome-specific selection mechanism is postulated.
- Subjects :
- Pathology
medicine.medical_specialty
Chorionic villus sampling
Prenatal diagnosis
Trisomy
Gastroenterology
Predictive Value of Tests
Pregnancy
Internal medicine
medicine
Humans
Genetics (clinical)
Chromosome Aberrations
medicine.diagnostic_test
business.industry
Mosaicism
Cytogenetics
Obstetrics and Gynecology
Karyotype
medicine.disease
medicine.anatomical_structure
Chorionic Villi Sampling
In utero
Predictive value of tests
Chorionic villi
Female
business
Subjects
Details
- ISSN :
- 01973851
- Volume :
- 10
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Prenatal diagnosis
- Accession number :
- edsair.doi.dedup.....5c23cee843477b73243481bda6392e11