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Expression and Significance of CD44, CD47 and c-met in Ovarian Clear Cell Carcinoma
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 16, Iss 2, Pp 3391-3404 (2015), Volume 16, Issue 2, Pages 3391-3404
- Publication Year :
- 2015
- Publisher :
- MDPI, 2015.
-
Abstract
- Aims: The aim of the present study is to investigate the differential expression of CD44, CD47 and c-met in ovarian clear cell carcinoma (OCCC), the correlation in their expression and their relationship with the biological behavior of OCCC. Methods: We used immunohistochemistry to examine the expression of CD44, CD47 and c-met in OCCC (86 cases) and investigated the effects of the expression and interaction of these molecules on the development of OCCC. Results: CD44, CD47 and c-met expression was significantly high in OCCC. Expression of CD44 and CD47 correlated with patient surgical stage, chemotherapy resistance and prognosis (all p &lt<br />0.05), and expression of c-met correlated with chemotherapy resistance and prognosis (all p &lt<br />0.05), but did not correlate with lymph node metastasis (all p &gt<br />0.05). The surgical stage, CD44, CD47 and c-met expression were independent risk factors for OCCC prognosis (all p &lt<br />0.05). Patients with low levels of CD44, CD47 and c-met showed better survival than those with high levels (all p &lt<br />0.05). There was a positive correlation between CD44 (or CD47) and c-met, as well as between CD44 and CD47 (the Spearman correlation coefficient rs was 0.783, 0.776 and 0.835, respectively, all p &lt<br />0.01). Additionally, pairwise correlation analysis of these three markers shows that the high expression of CD44/CD47, CD44/c-met and CD47/c-met were correlated with patient surgical stage, chemotherapy resistance and prognosis (all p &lt<br />0.05). Conclusions: Expression of CD44, CD47 and c-met was upregulated in OCCC and pairwise correlation. CD44, CD47 and c-met may have synergistic effects on the development of OCCC and are prognostic factors for ovarian cancer.
- Subjects :
- Oncology
lcsh:Chemistry
chemistry.chemical_compound
Stage (cooking)
CD44
CD47
lcsh:QH301-705.5
Spectroscopy
Regulation of gene expression
Ovarian Neoplasms
General Medicine
Middle Aged
Proto-Oncogene Proteins c-met
Prognosis
Immunohistochemistry
Computer Science Applications
Gene Expression Regulation, Neoplastic
Hyaluronan Receptors
Lymphatic Metastasis
Clear cell carcinoma
Adenocarcinoma
Female
Adult
medicine.medical_specialty
C-Met
CD47 Antigen
Biology
Catalysis
Article
Inorganic Chemistry
Internal medicine
medicine
Biomarkers, Tumor
Humans
Physical and Theoretical Chemistry
Molecular Biology
Aged
Neoplasm Staging
Organic Chemistry
medicine.disease
ovarian clear cell carcinoma
lcsh:Biology (General)
lcsh:QD1-999
chemistry
Cancer research
biology.protein
Ovarian cancer
c-met
Adenocarcinoma, Clear Cell
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 16
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....5c25f6c4332d702dedc86e761a9dd67c