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Variation in Gamma Interferon Responses to Different Infecting Strains of Mycobacterium tuberculosis in Acid-Fast Bacillus Smear-Positive Patients and Household Contacts in Antananarivo, Madagascar
- Source :
- Clinical and Vaccine Immunology, Clinical and Vaccine Immunology, American Society for Microbiology, 2010, 17 (7), pp.1094-103. ⟨10.1128/CVI.00049-10⟩, Clinical and Vaccine Immunology, 2010, 17 (7), pp.1094-103. ⟨10.1128/CVI.00049-10⟩
- Publication Year :
- 2010
- Publisher :
- American Society for Microbiology, 2010.
-
Abstract
- The majority of healthy individuals exposed to Mycobacterium tuberculosis will not develop tuberculosis (TB), though many may become latently infected. More precise measurement of the human immune response to M. tuberculosis infection may help us understand this difference and potentially identify those subjects most at risk of developing active disease. Gamma interferon (IFN-γ) production has been widely used as a proxy marker to study infection and to examine the human immune response to specific M. tuberculosis antigens. It has been suggested that genetically distinct M. tuberculosis strains may invoke different immune responses, although how these differences influence the immune responses and clinical outcome in human tuberculosis is still poorly understood. We therefore evaluated the antigen-specific IFN-γ production responses in peripheral blood mononuclear cells from two cohorts of subjects recruited in Antananarivo, Madagascar, from 2004 to 2006 and examined the influence of the infecting M. tuberculosis strains on this response. The cohorts were sputum-positive index cases and their household contacts. Clinical strains isolated from the TB patients were typed by spoligotyping. Comparison of the IFN-γ responses with the spoligotype of the infecting clinical strains showed that “modern” M. tuberculosis strains, like Beijing and Central Asian (CAS) strains, tended to induce lower IFN-γ responses than “ancient” strains, like East African-Indian (EAI) strains, in index cases and their household contacts. These results suggest that new strains may have evolved to induce a host response different from that of ancient strains. These findings could have important implications in the development of therapeutic and diagnostic strategies.
- Subjects :
- Microbiology (medical)
MESH: Mycobacterium tuberculosis
Tuberculosis
MESH: Interferon-gamma
Clinical Biochemistry
Immunology
Virulence
Disease
MESH: Madagascar
Mycobacterium tuberculosis
Interferon-gamma
03 medical and health sciences
Immune system
Species Specificity
Antigen
Genotype
Madagascar
IFN-gamma response
medicine
Clinical Laboratory Immunology
Humans
MESH: Species Specificity
Immunology and Allergy
MESH: Data Collection
Interferon gamma
030304 developmental biology
Antigens, Bacterial
[SDV.GEN]Life Sciences [q-bio]/Genetics
0303 health sciences
MESH: Humans
spoligotyping
biology
030306 microbiology
Data Collection
MESH: Host-Pathogen Interactions
biology.organism_classification
medicine.disease
Virology
3. Good health
MESH: Leukocytes, Mononuclear
M. tuberculosis genotype
Host-Pathogen Interactions
Leukocytes, Mononuclear
[SDV.IMM]Life Sciences [q-bio]/Immunology
MESH: Antigens, Bacterial
medicine.drug
Subjects
Details
- ISSN :
- 1556679X and 15566811
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Clinical and Vaccine Immunology
- Accession number :
- edsair.doi.dedup.....5c2cf65a5d02a70f8906c01a3ecec41b