Back to Search
Start Over
Genetic variability of the mTOR pathway and prostate cancer risk in the European Prospective Investigation on Cancer (EPIC)
- Source :
- PLoS ONE, PLoS ONE, Public Library of Science, 2011, 6 (2), pp.e16914. ⟨10.1371/journal.pone.0016914⟩, Campa, D, Hüsing, A, Stein, A, Dostal, L, Boeing, H, Pischon, T, Tjønneland, A, Roswall, N, Overvad, K, Østergaard, J N, Rodríguez, L, Sala, N, Sánchez, M-J, Larrañaga, N, Huerta, J M, Barricarte, A, Khaw, K-T, Wareham, N, Travis, R C, Allen, N E, Lagiou, P, Trichopoulou, A, Trichopoulos, D, Palli, D, Sieri, S, Tumino, R, Sacerdote, C, van Kranen, H, Bueno-de-Mesquita, H B, Hallmans, G, Johansson, M, Romieu, I, Jenab, M, Cox, D G, Siddiq, A, Riboli, E, Canzian, F & Kaaks, R 2011, ' Genetic Variability of the mTOR Pathway and Prostate Cancer Risk in the European Prospective Investigation on Cancer (EPIC) ', P L o S One, vol. 6, no. 2, pp. e16914 . https://doi.org/10.1371/journal.pone.0016914, PLoS ONE, Public Library of Science, 2011, 6 (2), pp.e16914. 〈10.1371/journal.pone.0016914〉, Dipòsit Digital de la UB, Universidad de Barcelona, PLoS ONE, Vol 6, Iss 2, p e16914 (2011), Recercat. Dipósit de la Recerca de Catalunya, instname
- Publication Year :
- 2011
- Publisher :
- Public Library of Science, 2011.
-
Abstract
- International audience; The mTOR (mammalian target of rapamycin) signal transduction pathway integrates various signals, regulating ribosome biogenesis and protein synthesis as a function of available energy and amino acids, and assuring an appropriate coupling of cellular proliferation with increases in cell size. In addition, recent evidence has pointed to an interplay between the mTOR and p53 pathways. We investigated the genetic variability of 67 key genes in the mTOR pathway and in genes of the p53 pathway which interact with mTOR. We tested the association of 1,084 tagging SNPs with prostate cancer risk in a study of 815 prostate cancer cases and 1,266 controls nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). We chose the SNPs (n = 11) with the strongest association with risk (p
- Subjects :
- Oncology
Male
MESH: Carcinoma
Epidemiology
protein p53
MESH : Aged
PROTEIN
Genome-wide association study
MESH : Genotype
[ SDV.CAN ] Life Sciences [q-bio]/Cancer
KAPPA-B ACTIVATION
MESH: Genotype
0302 clinical medicine
PKC-IOTA
Epidemiology of cancer
Multicenter Studies as Topic
TUBEROUS SCLEROSIS
MESH: Genetic Variation
lcsh:Science
MESH : Isoenzymes
0303 health sciences
MESH: Middle Aged
MESH : Carcinoma
TOR Serine-Threonine Kinases
Cancer Risk Factors
target of rapamycin kinase
MTOR protein
MESH: Case-Control Studies
3. Good health
030220 oncology & carcinogenesis
Medicine
Science & Technology - Other Topics
MESH : Genome-Wide Association Study
Phenomena and Processes::Genetic Phenomena::Genetic Variation [Medical Subject Headings]
MESH : Prostatic Neoplasms
Phenomena and Processes::Chemical Phenomena::Chemical Processes::Biochemical Processes::Signal Transduction [Medical Subject Headings]
medicine.medical_specialty
MESH : Case-Control Studies
Genotype
Single-nucleotide polymorphism
Variación genética
03 medical and health sciences
Genetics
Cancer Genetics
Humans
MESH : Middle Aged
human
Biology
mammalian target of rapamycin
Aged
Estudio Multicéntrico
Science & Technology
MESH: Humans
MULTIDISCIPLINARY SCIENCES
lcsh:R
MESH : Humans
Genetic Variation
medicine.disease
MESH : Neoplasms
Genitourinary Tract Tumors
Genetic epidemiology
Cardiovascular and Metabolic Diseases
Case-Control Studies
KINASE-C-IOTA
MESH: Genome-Wide Association Study
MESH: Multicenter Studies as Topic
lcsh:Q
MESH : Genetic Predisposition to Disease
RAPAMYCIN
Lifestyle Causes of Cancer
MESH: Signal Transduction
Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Clinical Trials as Topic::Multicenter Studies as Topic [Medical Subject Headings]
lcsh:Medicine
Bioinformatics
MESH : Multicenter Studies as Topic
Prostate cancer
Risk Factors
MESH: Risk Factors
Neoplasms
Clinical Epidemiology
MESH: Neoplasms
Protein Kinase C
MESH: Aged
Multidisciplinary
Prostate Cancer
MESH: Genetic Predisposition to Disease
Middle Aged
MESH : Risk Factors
European Prospective Investigation into Cancer and Nutrition
Europe
Isoenzymes
Diseases::Male Urogenital Diseases::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms [Medical Subject Headings]
Genetic Epidemiology
protein kinase C lambda
MESH: Isoenzymes
MESH : TOR Serine-Threonine Kinases
isoenzyme
Cancer Epidemiology
Signal Transduction
Research Article
MESH : Male
Genetic Causes of Cancer
MESH : Europe
[SDV.CAN]Life Sciences [q-bio]/Cancer
Neoplasias de la Próstata
Genetic polymorphisms
Serina-Treonina Quinasas TOR
Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies [Medical Subject Headings]
Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Disease [Medical Subject Headings]
LUNG-CANCER
MESH : Genetic Variation
Internal medicine
medicine
Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Intracellular Signaling Peptides and Proteins::TOR Serine-Threonine Kinases [Medical Subject Headings]
Genetic Predisposition to Disease
MESH : Protein Kinase C
PI3K/AKT/mTOR pathway
Genetic Association Studies
MESH: TOR Serine-Threonine Kinases
030304 developmental biology
MESH : Signal Transduction
COMPLEX
Càncer de pròstata
Polimorfisme genètic
Carcinoma
MTOR protein, human
protein kinase C
Cancer
Prostatic Neoplasms
Cancers and Neoplasms
Human Genetics
MESH: Protein Kinase C
MESH: Male
MAMMALIAN TARGET
MESH: Prostatic Neoplasms
CELL-GROWTH
MESH: Europe
EPIC
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, PLoS ONE, Public Library of Science, 2011, 6 (2), pp.e16914. ⟨10.1371/journal.pone.0016914⟩, Campa, D, Hüsing, A, Stein, A, Dostal, L, Boeing, H, Pischon, T, Tjønneland, A, Roswall, N, Overvad, K, Østergaard, J N, Rodríguez, L, Sala, N, Sánchez, M-J, Larrañaga, N, Huerta, J M, Barricarte, A, Khaw, K-T, Wareham, N, Travis, R C, Allen, N E, Lagiou, P, Trichopoulou, A, Trichopoulos, D, Palli, D, Sieri, S, Tumino, R, Sacerdote, C, van Kranen, H, Bueno-de-Mesquita, H B, Hallmans, G, Johansson, M, Romieu, I, Jenab, M, Cox, D G, Siddiq, A, Riboli, E, Canzian, F & Kaaks, R 2011, ' Genetic Variability of the mTOR Pathway and Prostate Cancer Risk in the European Prospective Investigation on Cancer (EPIC) ', P L o S One, vol. 6, no. 2, pp. e16914 . https://doi.org/10.1371/journal.pone.0016914, PLoS ONE, Public Library of Science, 2011, 6 (2), pp.e16914. 〈10.1371/journal.pone.0016914〉, Dipòsit Digital de la UB, Universidad de Barcelona, PLoS ONE, Vol 6, Iss 2, p e16914 (2011), Recercat. Dipósit de la Recerca de Catalunya, instname
- Accession number :
- edsair.doi.dedup.....5c55135331fb7c7ac6f04ea0f4de4500