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Acute and long-term antihypertensive effect of bopindolol once daily or once weekly
- Source :
- Journal of cardiovascular pharmacology. 8
- Publication Year :
- 1986
-
Abstract
- Fourteen male patients, mean age 53 years (range 35-64), were included in an initial 3 months' double-blind crossover study, in which 1-2 mg bopindolol, a nonselective beta blocker with intrinsic sympathomimetic activity (ISA), was compared with 100-200 mg metoprolol regarding effects on blood pressure and heart rate. During the subsequent long-term therapy, eight patients were trained to measure home blood pressure, and in these patients bopindolol 1 mg daily was compared to 8 mg once weekly in a double-blind fashion for 3 weeks on each regimen. Bopindolol (mean dose 1.35 mg/day) caused a significant blood pressure reduction, 26/15 mm Hg, as did metoprolol, 24/3 mm Hg (mean dose 144 mg/day) (NS). Supine and standing heart rates were reduced during both bopindolol and metoprolol treatment. During long-term therapy with bopindolol satisfactory blood pressure control was achieved for 1 year in 11 patients. Heart rate was significantly reduced after 2-3 months' treatment and during the entire 1-year follow-up. Few and well-tolerated side effects were reported. During treatment with bopindolol 8 mg once weekly, the blood pressure control was maintained satisfactorily over the week and no significant differences were observed in comparison with daily administration (1 mg) of the drug.
- Subjects :
- Adult
Male
Supine position
Time Factors
medicine.drug_class
Adrenergic beta-Antagonists
Blood Pressure
Drug Administration Schedule
Heart Rate
Heart rate
medicine
Humans
Beta blocker
Antihypertensive Agents
Metoprolol
Pharmacology
Bopindolol
business.industry
Crossover study
Regimen
Blood pressure
Anesthesia
Pindolol
Cardiology and Cardiovascular Medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 01602446
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of cardiovascular pharmacology
- Accession number :
- edsair.doi.dedup.....5c76fcf9298912ce712a4e17509c4d21