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Cecropin Suppresses Human Hepatocellular Carcinoma BEL-7402 Cell Growth and Survival in vivo without Side-Toxicity
- Source :
- Asian Pacific Journal of Cancer Prevention. 15:5433-5436
- Publication Year :
- 2014
- Publisher :
- Asian Pacific Organization for Cancer Prevention, 2014.
-
Abstract
- Conventional chemotherapy against hepatocellular carcinoma typically causes various side effects. Our previous study showed that cecropin of Musca domestica can induce apoptosis in human hepatocellular carcinoma BEL-7402 cells in vitro. However, whether cecropin inhibits BEL-7402 cell in vivo and the question of possible side effects remained undentified. The present study confirmed tumor-inhibitory effects of cecropin in vivo, and furthermore strongly suggested that cecropin cytotoxicity in BEL-7402 cells in vivo may be mainly derived from its pro-apoptotic action. Specifically, we found that cecropin exerted no obvious side effects in tumor-bearing mice as it had no significant hematoxicity as well as visceral toxicity. Therefore, cecropin may be a potential candidate for further investigation as an antitumor agent against hepatocellular carcinoma.
- Subjects :
- Cancer Research
Carcinoma, Hepatocellular
animal structures
Epidemiology
Cell
Mice, Nude
Antineoplastic Agents
Apoptosis
Biology
Cell Line
Mice
In vivo
Cell Line, Tumor
Chlorocebus aethiops
medicine
Animals
Humans
Cytotoxicity
Cell Proliferation
Cell growth
Cecropins
Liver Neoplasms
fungi
Public Health, Environmental and Occupational Health
medicine.disease
medicine.anatomical_structure
Cecropin
Oncology
Cell culture
Hepatocellular carcinoma
COS Cells
Immunology
Cancer research
Female
Subjects
Details
- ISSN :
- 15137368
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Asian Pacific Journal of Cancer Prevention
- Accession number :
- edsair.doi.dedup.....5c7fd19c85f3a1e81680698dd761ae54