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Diabetes and pancreatic neuroendocrine tumours: Which interplays, if any?
- Publication Year :
- 2018
-
Abstract
- Pancreatic neuroendocrine tumours (PanNETs) represent an uncommon type of pancreatic neoplasm, whose incidence is increasing worldwide. As per exocrine pancreatic cancer, a relationship seems to exist between PanNETs and glycaemic alterations. Diabetes mellitus (DM) or impaired glucose tolerance often occurs in PanNET patients as a consequence of hormonal hypersecretion by the tumour, specifically affecting glucose metabolism, or due to tumour mass effects. On the other hand, pre-existing DM may represent a risk factor for developing PanNETs and is likely to worsen the prognosis of such patients. Moreover, the surgical and/or pharmacological treatment of the tumour itself may impair glucose tolerance, as well as antidiabetic therapies may impact tumour behaviour and patients outcome. Differently from exocrine pancreatic tumours, few data are available for PanNETs as yet on this issue. In the present review, the bidirectional association between glycaemic disorders and PanNETs has been extensively examined, since the co-existence of both diseases in the same individual represents a further challenge for the clinical management of PanNETs.
- Subjects :
- Oncology
medicine.medical_specialty
Radiology, Nuclear Medicine and Imaging
Prognosi
030209 endocrinology & metabolism
Diabete
Pharmacological treatment
nuclear medicine and imaging
Diabetes Complications
Impaired glucose tolerance
03 medical and health sciences
0302 clinical medicine
Diabetes
lifestyle
neuroendocrine tumours
nutrition
therapy
diabetes complications
diabetes mellitus
humans
hypoglycemic agents
neuroendocrine tumors
pancreatic neoplasms
prognosis
oncology
radiology
Diabetes mellitus
Internal medicine
Diabetes Complication
Neuroendocrine tumour
Diabetes Mellitus
Humans
Hypoglycemic Agents
Medicine
Neoplasm
Risk factor
Nutrition
Hypoglycemic Agent
business.industry
Pancreatic Neoplasm
Diabetes Mellitu
General Medicine
Prognosis
medicine.disease
Lifestyle
Pancreatic Neoplasms
Neuroendocrine Tumors
030220 oncology & carcinogenesis
Exocrine pancreatic cancer
Therapy
business
Neuroendocrine Tumor
Hormone
Human
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....5c963d9437db0bf21fce7c65f3ac2c69