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Foot ischemia related to essential thrombocytemia and atherosclerosis
- Source :
- JMV-Journal de Médecine Vasculaire. 46:123-128
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- We report two cases of foot ischemia combining microvascular thrombosis related to essential thrombocytemia (ET) and a proximal ulcerating atherosclerotic plaque. This suggests that myeloproliferative neoplasms could also trigger distal embolism from an unstable atherosclerotic plaque by creating a prothrombotic status. These distal ischemic events were the first ET manifestation and therefore lead to myeloproliferative neoplasm diagnosis. In ET, thrombosis event can occur with a normal platelet count. Furthermore, hemogram should be regularly controlled among JAK2 muted patients considering the frequent evolution from isolated JAK2 mutation to ET.
- Subjects :
- medicine.medical_specialty
Essential Thrombocytemia
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Ischemia
Internal medicine
medicine
Humans
Platelet
Foot ischemia
Myeloproliferative neoplasm
Myeloproliferative Disorders
Microvascular thrombosis
business.industry
Jak2 mutation
Thrombosis
Atherosclerosis
medicine.disease
Embolism
Cardiology
Cardiology and Cardiovascular Medicine
business
Thrombocythemia, Essential
030215 immunology
Subjects
Details
- ISSN :
- 25424513
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- JMV-Journal de Médecine Vasculaire
- Accession number :
- edsair.doi.dedup.....5ca54df9d00364368b7d3ea859b0d8fd