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The Effect of Calcium-Silicate Cements on Reparative Dentinogenesis Following Direct Pulp Capping on Animal Models
- Source :
- Molecules, Vol 26, Iss 2725, p 2725 (2021), Molecules
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Dental pulp vitality is a desideratum for preserving the health and functionality of the tooth. In certain clinical situations that lead to pulp exposure, bioactive agents are used in direct pulp-capping procedures to stimulate the dentin-pulp complex and activate reparative dentinogenesis. Hydraulic calcium-silicate cements, derived from Portland cement, can induce the formation of a new dentin bridge at the interface between the biomaterial and the dental pulp. Odontoblasts are molecularly activated, and, if necessary, undifferentiated stem cells in the dental pulp can differentiate into odontoblasts. An extensive review of literature was conducted on MedLine/PubMed database to evaluate the histological outcomes of direct pulp capping with hydraulic calcium-silicate cements performed on animal models. Overall, irrespective of their physico-chemical properties and the molecular mechanisms involved in pulp healing, the effects of cements on tertiary dentin formation and pulp vitality preservation were positive. Histological examinations showed different degrees of dental pulp inflammatory response and complete/incomplete dentin bridge formation during the pulp healing process at different follow-up periods. Calcium silicate materials have the ability to induce reparative dentinogenesis when applied over exposed pulps, with different behaviors, as related to the animal model used, pulpal inflammatory responses, and quality of dentin bridges.
- Subjects :
- Ceramics
Reparative dentinogenesis
Pharmaceutical Science
Dentistry
dentin bridge
Organic chemistry
Biocompatible Materials
Review
Dental Pulp Capping
Analytical Chemistry
law.invention
chemistry.chemical_compound
0302 clinical medicine
QD241-441
law
Drug Discovery
Dentin
Aluminum Compounds
0303 health sciences
Chemistry
Biomaterial
Oxides
Drug Combinations
medicine.anatomical_structure
Chemistry (miscellaneous)
Models, Animal
Calcium silicate
direct pulp capping
Molecular Medicine
dental pulp
biomaterials
Dentin, Secondary
Dental Materials
03 medical and health sciences
Dogs
stomatognathic system
medicine
Animals
Humans
Physical and Theoretical Chemistry
030304 developmental biology
Inflammation
business.industry
Silicates
030206 dentistry
Calcium Compounds
Dentinogenesis
Pulp capping
Portland cement
stomatognathic diseases
Odontoblast
Pulp (tooth)
business
calcium-silicate cements
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 26
- Issue :
- 2725
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....5ca6634bc1bfe04d358cb89df660ae16