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New Strategies in Prostate Cancer: Targeting Lipogenic Pathways and the Energy Sensor AMPK
- Source :
- Clinical Cancer Research. 16:3322-3328
- Publication Year :
- 2010
- Publisher :
- American Association for Cancer Research (AACR), 2010.
-
Abstract
- Although the role of metabolic syndrome (MS) and a high fat diet in prostate cancer (PCa) risk is still a matter of intense debate, it is becoming increasingly clear that obesity can cause perturbations in metabolic pathways that contribute to the pathogenesis and progression of PCa. Moreover, prostate epithelial cells per se undergo a series of metabolic changes, including an increase in de novo lipogenesis, during the process of tumor formation. These metabolic alterations, at both the cellular and organismal levels, are intertwined with genetic aberrations necessary for neoplastic transformation. Thus, altered metabolism is currently subject to intense research efforts and might provide preventative and therapeutic opportunities, as well as a platform for biomarker development. In this article, we review evidence that the metabolic sensor 5′-AMP-activated protein kinase (AMPK), which physiologically integrates nutritional and hormonal signals and regulates cell survival and growth-related metabolic pathways to preserve intracellular ATP levels, represents a link between energy homeostasis and cancer. Thus, when AMPK is not activated, as in the setting of MS and obesity, systemic metabolic alterations permissive to the development of PCa are allowed to proceed unchecked. Hence, the use of AMPK activators and inhibitors of key lipogenic enzymes may represent a promising therapeutic strategy for PCa. Clin Cancer Res; 16(13); 3322–8. ©2010 AACR.
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
AMP-Activated Protein Kinases
Protein Serine-Threonine Kinases
Biology
Article
Energy homeostasis
Prostate cancer
AMP-activated protein kinase
Internal medicine
medicine
Humans
Neoplastic transformation
Obesity
Metabolic Syndrome
Lipogenesis
TOR Serine-Threonine Kinases
Intracellular Signaling Peptides and Proteins
Prostatic Neoplasms
AMPK
medicine.disease
Dietary Fats
Biomarker (cell)
Metabolic pathway
Endocrinology
Oncology
Cancer research
biology.protein
Energy Metabolism
Signal Transduction
Subjects
Details
- ISSN :
- 15573265 and 10780432
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Clinical Cancer Research
- Accession number :
- edsair.doi.dedup.....5ce3b28fc6b7cf2d6d2172b3018f694a