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Cytokine release from microglia: differential inhibition by pentoxifylline and dexamethasone
- Source :
- The Journal of infectious diseases. 166(4)
- Publication Year :
- 1992
-
Abstract
- Cytokines have been implicated in the pathogenesis of gram-negative bacterial meningitis. The effects of pentoxifylline and dexamethasone on the release of tumor necrosis factor (TNF), interleukin (IL)-1, and IL-6 from primary murine microglial cell cultures were explored using bioassays. When added concomitantly with lipopolysaccharide, pentoxifylline blocked the release of TNF and IL-1 but not IL-6, while dexamethasone inhibited the release of TNF and IL-6. After a 2-h exposure of microglia to lipopolysaccharide, pentoxifylline but not dexamethasone still inhibited the release of TNF. Release of TNF was enhanced 20-fold by priming of the microglia with interferon-gamma; only pentoxifylline blocked the priming effect of interferon-gamma on TNF release. These results demonstrate that pentoxifylline and dexamethasone differentially regulate the release of cytokines in microglial cell cultures and provide potential insight into their role in the treatment of gram-negative bacterial meningitis.
- Subjects :
- Lipopolysaccharides
medicine.medical_specialty
Lipopolysaccharide
medicine.medical_treatment
Biology
Dexamethasone
Pentoxifylline
chemistry.chemical_compound
Mice
Internal medicine
medicine
Immunology and Allergy
Animals
Interleukin 6
Cells, Cultured
Mice, Inbred BALB C
Microglia
Interleukin-6
Tumor Necrosis Factor-alpha
Interleukin
Brain
Infectious Diseases
medicine.anatomical_structure
Cytokine
Endocrinology
chemistry
biology.protein
Tumor necrosis factor alpha
medicine.drug
Interleukin-1
Subjects
Details
- ISSN :
- 00221899
- Volume :
- 166
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The Journal of infectious diseases
- Accession number :
- edsair.doi.dedup.....5ce881c7e1aa90b07aa362505e1ebb77