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Anopheles Salivary Biomarker to Assess Malaria Transmission Risk Along the Thailand-Myanmar Border
- Source :
- Journal of Infectious Diseases, Journal of Infectious Diseases, Oxford University Press (OUP), 2016, pp.jiw543. ⟨10.1093/infdis/jiw543⟩
- Publication Year :
- 2016
- Publisher :
- Oxford University Press (OUP), 2016.
-
Abstract
- Author(s): Ya-Umphan, Phubeth; Cerqueira, Dominique; Parker, Daniel M; Cottrell, Gilles; Poinsignon, Anne; Remoue, Franck; Brengues, Cecile; Chareonviriyaphap, Theeraphap; Nosten, Francois; Corbel, Vincent | Abstract: BackgroundThe modalities of malaria transmission along the Thailand-Myanmar border are poorly understood. Here we address the relevance of using a specific Anopheles salivary biomarker to measure the risk among humans of exposure to Anopheles bites.MethodsSerologic surveys were conducted from May 2013 to December 2014 in 4 sentinel villages. More than 9400 blood specimens were collected in filter papers from all inhabitants at baseline and then every 3 months thereafter, for up to 18 months, for analysis by enzyme-linked immunosorbent assay. The relationship between the intensity of the human antibody response and entomological indicators of transmission (human biting rates and entomological inoculation rates [EIRs]) was studied using a multivariate 3-level mixed model analysis. Heat maps for human immunoglobulin G (IgG) responses for each village and survey time point were created using QGIS 2.4.ResultsThe levels of IgG response among participants varied significantly according to village, season, and age (Pl.001) and were positively associated with the abundance of total Anopheles species and primary malaria vectors and the EIR (Pl.001). Spatial clusters of high-IgG responders were identified across space and time within study villages.ConclusionsThe gSG6-P1 biomarker has great potential to address the risk of transmission along the Thailand-Myanmar border and represents a promising tool to guide malaria interventions.
- Subjects :
- Male
0301 basic medicine
Myanmar
law.invention
Cohort Studies
0302 clinical medicine
law
Immunology and Allergy
Child
Salivary biomarkers
Malaria vector
ComputingMilieux_MISCELLANEOUS
response
transmission
Salivary Biomarker
Anopheles
Middle Aged
Thailand
3. Good health
Infectious Diseases
Transmission (mechanics)
Child, Preschool
Insect Proteins
[SDV.IMM]Life Sciences [q-bio]/Immunology
Biomarker (medicine)
Female
human antibody
Adult
malaria vectors
Adolescent
030231 tropical medicine
Biology
Human Immunoglobulin G
Young Adult
03 medical and health sciences
Malaria transmission
parasitic diseases
Major Article
medicine
Animals
Humans
Salivary Proteins and Peptides
Aged
Infant, Newborn
Thailand-Myanmar border
Infant
Insect Bites and Stings
Environmental Exposure
medicine.disease
biology.organism_classification
Malaria
030104 developmental biology
Immunoglobulin G
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
gSG6-P1
Biomarkers
Demography
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Database :
- OpenAIRE
- Journal :
- Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....5cf34f97857b0095b3a608d63090d90b