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Serum Heart-Type Fatty Acid-Binding Protein and Cerebrospinal Fluid Tau: Marker Candidates for Dementia with Lewy Bodies
- Source :
- Neurodegenerative Diseases. 4:366-375
- Publication Year :
- 2007
- Publisher :
- S. Karger AG, 2007.
-
Abstract
- Background: The measurement of biomarkers in cerebrospinal fluid (CSF) has gained increasing acceptance in establishing the diagnosis of some neurodegenerative diseases. Heart-type fatty acid-binding protein (H-FABP) was recently discovered in CSF and serum of patients with neurodegenerative diseases. Objective: We investigated H-FABP in CSF and serum alone and in combination with CSF tau protein to evaluate these as potential biomarkers for the differentiation between dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD). Methods: We established H-FABP and tau protein values in a set of 144 persons with DLB (n = 33), Parkinson disease with dementia (PDD; n = 25), AD (n = 35) and nondemented neurological controls (NNC; n = 51). Additionally, serum H-FABP levels were analyzed in idiopathic Parkinson disease patients without evidence of cognitive decline (n = 45) using commercially available enzyme-linked immunosorbent assays. We calculated absolute values of H-FABP and tau protein in CSF and serum and established relative ratios between the two to obtain the best possible match for the clinical working diagnosis. Results: Serum H-FABP levels were elevated in DLB and PDD patients compared with NNC and AD subjects. To better discriminate between DLB and AD, we calculated the ratio of serum H-FABP to CSF tau protein levels. At the arbitrary chosen cutoff ratio ≧8 this quotient reached a sensitivity of 91% and a specificity of 66%. Conclusion: Our results suggest that the measurement of CSF tau protein, together with H-FABP quantification in serum and CSF, and the ratio of serum H-FABP to CSF tau protein represent marker candidates for the differentiation between AD and DLB.
- Subjects :
- Lewy Body Disease
Male
medicine.medical_specialty
Pathology
Medizinische Fakultät -ohne weitere Spezifikation
Tau protein
tau Proteins
Fatty Acid-Binding Proteins
Cohort Studies
Diagnosis, Differential
Cerebrospinal fluid
Alzheimer Disease
Predictive Value of Tests
Internal medicine
mental disorders
Humans
Medicine
Dementia
ddc:610
Cognitive decline
Selection Bias
Aged
Aged, 80 and over
biology
business.industry
Dementia with Lewy bodies
Parkinson Disease
Working diagnosis
Middle Aged
medicine.disease
Cross-Sectional Studies
Endocrinology
Neurology
Heart-type fatty acid binding protein
Potential biomarkers
biology.protein
Female
lipids (amino acids, peptides, and proteins)
Neurology (clinical)
business
Fatty Acid Binding Protein 3
Biomarkers
Subjects
Details
- ISSN :
- 16602862 and 16602854
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Neurodegenerative Diseases
- Accession number :
- edsair.doi.dedup.....5d1b763052e97387359f17e6c7052be5