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Association Between Pre-Pregnancy Body Mass Index and Miscarriage in an Assisted Reproductive Technology Population: A 10-Year Cohort Study
- Source :
- Frontiers in Endocrinology, Frontiers in Endocrinology, Vol 12 (2021)
- Publication Year :
- 2021
- Publisher :
- Frontiers Media SA, 2021.
-
Abstract
- ObjectiveTo investigate the association between pre-pregnancy body mass index (BMI) and miscarriages in women who required assisted reproductive technology (ART) for conception.MethodsA retrospective cohort study was conducted using a 10-year (2006–2015) sample of 14,994 pregnancy cycles with ART treatment in Northwest Women’s and Children’s Hospital, Xi’an, China. The effects of women’s BMI before pregnancy on early miscarriage and miscarriage were assessed using generalized estimating equation models.ResultsThe risks of early miscarriage and miscarriage were higher in the obese group than in the normal weight group [early miscarriage: relative risk (RR) = 1.36, confidence interval (CI): 1.12–1.65; miscarriage: RR = 1.40, 95% CI: 1.17–1.68]. Pre-pregnancy underweight was not associated with an increased risk of early miscarriage or miscarriage. We observed interactions between pre-pregnancy BMI and singleton or twin pregnancy in early miscarriage and miscarriage (P = 0.017 and P = 0.003, respectively). Twin pregnancy increased the effects of pre-pregnancy BMI on early miscarriage and miscarriage (early miscarriage: a. singleton pregnancy: RR = 1.02, 95% CI: 1.01–1.04; b. twin pregnancy: RR = 1.08, 95% CI: 1.03–1.13; miscarriage: a. singleton pregnancy: RR = 1.02, 95% CI: 1.01–1.04; b. twin pregnancy: RR = 1.08, 95% CI: 1.05–1.13).ConclusionsPre-pregnancy obesity was associated with higher risks of early miscarriage and miscarriage in the ART population, and twin pregnancy increased the effects of pre-pregnancy BMI on early miscarriage and miscarriage. Women should maintain a normal BMI before ART initiation to prevent adverse pregnancy outcomes.
- Subjects :
- Adult
Risk
China
obesity
medicine.medical_specialty
Reproductive Techniques, Assisted
medicine.medical_treatment
Endocrinology, Diabetes and Metabolism
miscarriage
Population
body mass index
030209 endocrinology & metabolism
Diseases of the endocrine glands. Clinical endocrinology
Miscarriage
Cohort Studies
03 medical and health sciences
Endocrinology
0302 clinical medicine
Thinness
Pregnancy
assisted reproductive technology
Humans
Medicine
education
Twin Pregnancy
Retrospective Studies
Original Research
education.field_of_study
030219 obstetrics & reproductive medicine
Assisted reproductive technology
business.industry
Obstetrics
Pregnancy Outcome
twin pregnancy
RC648-665
medicine.disease
Abortion, Spontaneous
Pregnancy Complications
Fertilization
Pregnancy, Twin
Premature Birth
Female
Underweight
medicine.symptom
business
Body mass index
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 16642392
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in Endocrinology
- Accession number :
- edsair.doi.dedup.....5d61ff8effc5960feff040c795b72876
- Full Text :
- https://doi.org/10.3389/fendo.2021.646162