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Facile synthesis of novel carbon-dots/hemin nanoplatforms for synergistic photo-thermal and photo-dynamic therapies
- Source :
- Journal of Inorganic Biochemistry. 193:166-172
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Due to the traditional therapies of cancer inducing huge pains to patients, the non-invasive photo-guided therapies are attracting massive attentions of researchers. Herein, the intelligent-designed carbon-dots/hemin nanoplatforms (HCDs NPs) were developed, owning high-authority photo-therapy for cancer. The fluorescence resonance energy transfer (FRET) effect enhanced the photo-thermal ability of HCDs NPs, endowing the synthesized nanoplatforms with photo-dynamic property simultaneously. Therefore, the obtained HCDs NPs could achieve synergetic photo-thermal and photo-dynamic therapies for cancer. Basing on the experimental results, the prepared HCDs NPs could induce the temperature enhancement high to ca 26 °C under laser irradiation, also with the outstanding photo-dynamic efficacy. More than 90% of cancer cells die after 10 min laser treatment. Thus, the dual-modal photo-therapeutic HCDs NPs are promising and excellent nanomaterials for potential application in synergistic cancer therapy.
- Subjects :
- Light
genetic structures
Photo dynamic therapy
Cancer therapy
Antineoplastic Agents
Nanotechnology
010402 general chemistry
01 natural sciences
Biochemistry
Nanomaterials
Inorganic Chemistry
chemistry.chemical_compound
Quantum Dots
Fluorescence Resonance Energy Transfer
Humans
Particle Size
010405 organic chemistry
Chemistry
Laser treatment
Temperature
Hep G2 Cells
Hyperthermia, Induced
Carbon
0104 chemical sciences
Photochemotherapy
Solubility
Hemin
sense organs
Reactive Oxygen Species
Subjects
Details
- ISSN :
- 01620134
- Volume :
- 193
- Database :
- OpenAIRE
- Journal :
- Journal of Inorganic Biochemistry
- Accession number :
- edsair.doi.dedup.....5d6addcf0f5cb78af84796ba958d4dd4