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Treatment of acanthamoeba keratitis with intravenous pentamidine before therapeutic keratoplasty
- Source :
- Cornea. 34(1)
- Publication Year :
- 2014
-
Abstract
- Purpose The aim of this study was to evaluate the outcome of pretreatment of Acanthamoeba keratitis with intravenous pentamidine (IVP) before therapeutic keratoplasty (TKP). Methods A retrospective chart review was performed of the medical records of every patient treated with IVP before TKP for Acanthamoeba keratitis at a single, tertiary care eye center between January 1, 2002, and December 31, 2012. The main outcome measures were microbiological cure, graft survival, and visual outcome. Results Eight eyes of 7 patients met the inclusion criteria. Preoperatively, all 8 eyes had failed traditional antiamoebic therapy, including 5 eyes with recurrent infections after previous TKP. The patients were treated with IVP (190-400 mg/d) for a median of 14 days (range, 7-26 days). After 8 TKP, a microbiological cure was achieved, and a clear graft was maintained in 5 (62.5%) eyes during a mean follow-up interval of 31.2 months (range, 1.0-95.7 months). Repeat TKP in 3 eyes with recurrent Acanthamoeba keratitis resulted in 2 additional microbiological cures and 1 more clear graft. The final best-corrected visual acuity was ≥20/40 in 5 (62.5%) eyes and worse than 20/200 in 3 eyes. Overall, the final vision was improved in 6 (75.0%) eyes, remained the same in 1 (12.5%) eye, and was worse in 1 (12.5%) eye. Conclusions The adjunctive use of IVP before TKP may assist with the achievement of microbiological cure, clear graft, and good visual outcome in a majority of eyes with Acanthamoeba keratitis.
- Subjects :
- Adult
Male
medicine.medical_specialty
Visual acuity
genetic structures
Adolescent
Antiprotozoal Agents
Visual Acuity
Tertiary care
Young Adult
Recurrence
Chart review
Medicine
Humans
Infusions, Intravenous
Pentamidine
Retrospective Studies
business.industry
Medical record
Graft Survival
Outcome measures
Retrospective cohort study
Middle Aged
medicine.disease
eye diseases
Surgery
Ophthalmology
Acanthamoeba keratitis
Acanthamoeba Keratitis
Female
medicine.symptom
business
Keratoplasty, Penetrating
medicine.drug
Subjects
Details
- ISSN :
- 15364798
- Volume :
- 34
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cornea
- Accession number :
- edsair.doi.dedup.....5d6bae52abe34e0b063516836a5cab4d