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Therapeutic possibilities of 131I-MIBG in metastatic carcinoid tumors--preliminary report
- Source :
- Tumori. 76(5)
- Publication Year :
- 1990
-
Abstract
- The poor results of traditional therapy in advanced carcinoid tumors and the well-proven uptake of 131I-MIBG shown by some of these tumors induced us to attempt a radiometabolic approach. We selected for the treatment 5 patients (3 men and 2 women) who showed progression of disease, a fairly good uptake of 131l-MIBG with severe related symptoms, and a poor response to traditional therapy. A cumulative radioactivity of 5.5-29.6 GBq was given. Acute side effects after 131l-MIBG ad ministration or late radiation-induced damages were not observed. Symptoms increased during the first 2-4 weeks in 2 patients: in one of these relief was achieved with drugs. Results concerning objective remission of the disease were unsatisfactory. In contrast, definite improvement of symptoms was shown in 2 of 5 patients, resulting in a better quality of life.
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
Carcinoid tumors
Metastatic carcinoid
Carcinoid Tumor
030218 nuclear medicine & medical imaging
Iodine Radioisotopes
03 medical and health sciences
0302 clinical medicine
Preliminary report
medicine
Humans
Neoplasm Metastasis
Aged
business.industry
Iodobenzenes
General Medicine
Traditional therapy
Middle Aged
medicine.disease
3-Iodobenzylguanidine
Oncology
131i mibg
030220 oncology & carcinogenesis
Female
Radiology
business
Subjects
Details
- ISSN :
- 03008916
- Volume :
- 76
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Tumori
- Accession number :
- edsair.doi.dedup.....5d847613414f4981c19964c7b31948d0