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Serum Oxidized-LDL is Associated with Diabetes Duration Independent of Maintaining Optimized Levels of LDL-Cholesterol
- Source :
- Lipids. 45:321-327
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- Oxidized low-density lipoprotein (ox-LDL) plays a key role in the progression of atherosclerosis and diabetes complications. The aim of this study was first, to evaluate the association between ox-LDL and diabetes duration, and second, to examine serum level of ox-LDL in patients with prolonged diabetes and a desirable LDL-cholesterol level. A total of 36 type-2 diabetic patients with a diabetes duration of more than 5 years, 36 newly diagnosed diabetic patients, and 36 age-, sex- and BMI-matched healthy participants were recruited. Healthy participants and newly diagnosed patients were not receiving any treatment. All patients with prolonged diabetes had desirable LDL-cholesterol levels (100 mg/dL), according to the adult treatment panel-III guidelines. While LDL-cholesterol was significantly lower in patients with diabetes duration5 years, in comparison to newly diagnosed patients (P0.01), ox-LDL was significantly higher in patients with prolonged diabetes (P0.001). The ox-LDL-to-LDL ratio was dramatically higher in patients with diabetes duration5 years in comparison to newly diagnosed patients and healthy participants (P0.001). Ox-LDL was significantly associated with diabetes duration (r = 0.519, P = 0.001). In multivariate analysis, this association remained significant (beta = 0.501, P = 0.003) after adjustment for potential confounders. In conclusion, this study showed that the serum ox-LDL level increases with the length of diabetes, even though the patients' LDL-cholesterol level is maintained at a desirable level. Our findings highlight that possibly more attention should be focused on markers of oxidative stress in the management of lipids in diabetic patients.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Clinical chemistry
Cross-sectional study
Administration, Oral
Biochemistry
chemistry.chemical_compound
Internal medicine
Diabetes mellitus
medicine
Humans
Hypoglycemic Agents
Age of Onset
business.industry
Cholesterol
Organic Chemistry
Case-control study
Cholesterol, LDL
Cell Biology
Middle Aged
medicine.disease
Lipoproteins, LDL
Cross-Sectional Studies
Endocrinology
Diabetes Mellitus, Type 2
chemistry
Case-Control Studies
Multivariate Analysis
Female
lipids (amino acids, peptides, and proteins)
Age of onset
business
Lipoprotein
Lipidology
Subjects
Details
- ISSN :
- 15589307 and 00244201
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Lipids
- Accession number :
- edsair.doi.dedup.....5d9f17fbcd52b37a6aafabcb14559e6f