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Deep-AFPpred: identifying novel antifungal peptides using pretrained embeddings from seq2vec with 1DCNN-BiLSTM
- Source :
- Briefings in Bioinformatics. 23
- Publication Year :
- 2021
- Publisher :
- Oxford University Press (OUP), 2021.
-
Abstract
- Fungal infections or mycosis cause a wide range of diseases in humans and animals. The incidences of community acquired; nosocomial fungal infections have increased dramatically after the emergence of COVID-19 pandemic. The increase in number of patients with immunodeficiency / immunosuppression related diseases, resistance to existing antifungal compounds and availability of limited therapeutic options has triggered the search for alternative antifungal molecules. In this direction, antifungal peptides (AFPs) have received a lot of interest as an alternative to currently available antifungal drugs. Although the AFPs are produced by diverse population of living organisms, identifying effective AFPs from natural sources is time-consuming and expensive. Therefore, there is a need to develop a robust in silico model capable of identifying novel AFPs in protein sequences. In this paper, we propose Deep-AFPpred, a deep learning classifier that can identify AFPs in protein sequences. We developed Deep-AFPpred using the concept of transfer learning with 1DCNN-BiLSTM deep learning algorithm. The findings reveal that Deep-AFPpred beats other state-of-the-art AFP classifiers by a wide margin and achieved approximately 96% and 94% precision on validation and test data, respectively. Based on the proposed approach, an online prediction server is created and made publicly available at https://afppred.anvil.app/. Using this server, one can identify novel AFPs in protein sequences and the results are provided as a report that includes predicted peptides, their physicochemical properties and motifs. By utilizing this model, we identified AFPs in different proteins, which can be chemically synthesized in lab and experimentally validated for their antifungal activity.
- Subjects :
- Antifungal
2019-20 coronavirus outbreak
Antifungal Agents
Coronavirus disease 2019 (COVID-19)
SARS-CoV-2
medicine.drug_class
In silico
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Antifungal drugs
COVID-19
Computational biology
Biology
COVID-19 Drug Treatment
Diverse population
medicine
Humans
Mucormycosis
Peptides
Pandemics
Molecular Biology
Information Systems
Subjects
Details
- ISSN :
- 14774054 and 14675463
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Briefings in Bioinformatics
- Accession number :
- edsair.doi.dedup.....5dace11a805114775136a0f88c38b95b