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52 Genetic Loci Influencing Myocardial Mass
- Source :
- Elsevier, Journal of the American College of Cardiology, 68(13), 1435-1448. Elsevier Science, Journal of The American College of Cardiology, Journal of the American College of Cardiology, 68(13), 1435. Elsevier USA, van der Harst, P, van Setten, J, Verweij, N, Vogler, G, Franke, L, Maurano, M T, Wang, X, Mateo Leach, I, Eijgelsheim, M, Sotoodehnia, N, Hayward, C, Sorice, R, Meirelles, O, Lyytikäinen, L-P, Polašek, O, Tanaka, T, Arking, D E, Ulivi, S, Trompet, S, Müller-Nurasyid, M, Smith, A V, Dörr, M, Kerr, K F, Magnani, J W, Del Greco M, F, Zhang, W, Nolte, I M, Silva, C T, Padmanabhan, S, Tragante, V, Esko, T, Abecasis, G R, Adriaens, M E, Andersen, K, Barnett, P, Bis, J C, Bodmer, R, Buckley, B M, Campbell, H, Cannon, M V, Chakravarti, A, Chen, L Y, Delitala, A, Devereux, R B, Doevendans, P A, Dominiczak, A F, Ferrucci, L, Ford, I, Gieger, C, Harris, T B, Haugen, E, Heinig, M, Hernandez, D G, Hillege, H L, Hirschhorn, J N, Hofman, A, Hubner, N, Hwang, S-J, Iorio, A, Kähönen, M, Kellis, M, Kolcic, I, Kooner, I K, Kooner, J S, Kors, J A, Lakatta, E G, Lage, K, Launer, L J, Levy, D, Lundby, A, Macfarlane, P W, May, D, Meitinger, T, Metspalu, A, Nappo, S, Naitza, S, Neph, S, Nord, A S, Nutile, T, Okin, P M, Olsen, J V, Oostra, B A, Penninger, J M, Pennacchio, L A, Pers, T H, Perz, S, Peters, A, Pinto, Y M, Pfeufer, A, Pilia, M G, Pramstaller, P P, Prins, B P, Raitakari, O T, Raychaudhuri, S, Rice, K M, Rossin, E J, Rotter, J I, Schafer, S, Schlessinger, D, Schmidt, C O, Sehmi, J, Silljé, H H W, Sinagra, G, Sinner, M F, Slowikowski, K, Soliman, E Z, Spector, T D, Spiering, W, Stamatoyannopoulos, J A, Stolk, R P, Strauch, K, Tan, S-T, Tarasov, K V, Trinh, B, Uitterlinden, A G, van den Boogaard, M, van Duijn, C M, van Gilst, W H, Viikari, J S, Visscher, P M, Vitart, V, Völker, U, Waldenberger, M, Weichenberger, C X, Westra, H-J, Wijmenga, C, Wolffenbuttel, B H, Yang, J, Bezzina, C R, Munroe, P B, Snieder, H, Wright, A F, Rudan, I, Boyer, L A, Asselbergs, F W, van Veldhuisen, D J, Stricker, B H, Psaty, B M, Ciullo, M, Sanna, S, Lehtimäki, T, Wilson, J F, Bandinelli, S, Alonso, A, Gasparini, P, Jukema, J W, Kääb, S, Gudnason, V, Felix, S B, Heckbert, S R, de Boer, R A, Newton-Cheh, C, Hicks, A A, Chambers, J C, Jamshidi, Y, Visel, A, Christoffels, V M, Isaacs, A, Samani, N J & de Bakker, P I W 2016, ' 52 Genetic Loci Influencing Myocardial Mass ', Journal of the American College of Cardiology, vol. 68, no. 13, pp. 1435-1448 . https://doi.org/10.1016/j.jacc.2016.07.729, Journal of the American College of Cardiology, 68 (2016): 1435–1448. doi:10.1016/j.jacc.2016.07.729, info:cnr-pdr/source/autori:van der Harst, Pim; van Setten, Jessica; Verweij, Niek; Vogler, Georg; Franke, Lude; Maurano, Matthew T.; Wang, Xinchen; Leach, Irene Mateo; Eijgelsheim, Mark; Sotoodehnia, Nona; Hayward, Caroline; Sorice, Rossella; Meirelles, Osorio; Lyytikainen, Leo-Pekka; Polasek, Ozren; Tanaka, Toshiko; Arking, Dan E.; Ulivi, Sheila; Trompet, Stella; Mueller-Nurasyid, Martina; Smith, Albert V.; Doerr, Marcus; Kerr, Kathleen F.; Magnani, Jared W.; Del Greco, Fabiola; Zhang, Weihua; Nolte, Ilja M.; Silva, Claudia T.; Padmanabhan, Sandosh; Tragante, Vinicius; Esko, Tonu; Abecasis, Gonclo R.; Adriaens, Michiel E.; Andersen, Karl; Barnett, Phil; Bis, Joshua C.; Bodmer, Rolf; Buckley, Brendan M.; Campbell, Harry; Cannon, Megan V.; Chakravarti, Aravinda; Chen, Lin Y.; Delitala, Alessandro; Devereux, Richard B.; Doevendans, Pieter A.; Dominiczak, Anna F.; Ferrucci, Luigi; Ford, Ian; Gieger, Christian; Harris, Tamara B.; Haugen, Eric; Heinig, Matthias; Hernandez, Dena G.; Hillege, Hans L.; Hirschhorn, Joel N.; Hofman, Albert; Hubner, Norbert; Hwang, Shih-Jen; Iorio, Annamaria; Kahonen, Mika; Kellis, Manolis; Kolcic, Ivana; Kooner, Ishminder K.; Kooner, Jaspal S.; Kors, Jan A.; Lakatta, Edward G.; Lage, Kasper; Launer, Lenore J.; Levy, Daniel; Lundby, Alicia; Macfarlane, Peter W.; May, Dalit; Meitinger, Thomas; Metspalu, Andres; Nappo, Stefania; Naitza, Silvia; Neph, Shane; Nord, Alex S.; Nutile, Teresa; Okin, Peter M.; Olsen, Jesper V.; Oostra, Ben A.; Penninger, Josef M.; Pennacchio, Len A.; Pers, Tune H.; Perz, Siegfried; Peters, Annette; Pinto, Yigal M.; Pfeufer, Arne; Pilia, Maria Grazia; Pramstaller, Peter P.; Prins, Bram P.; Raitakari, Olli T.; Raychaudhuri, Soumya; Rice, Ken M.; Rossin, Elizabeth J.; Rotter, Jerome I.; Schafer, Sebastian; Schlessinger, David; Schmidt, Carsten O.; Sehmi, Jobanpreet; Sillje, Herman H. W.; Sinagra, Gianfranco; Sinner, Moritz F.; Slowikowski, Kamil; Soliman, Elsayed Z.; Spector, Timothy D.; Spiering, Wilko; Stamatoyannopoulos, John A.; Stolk, Ronald P.; Strauch, Konstantin; Tan, Sian-Tsung; Tarasov, Kirill V.; Trinh, Bosco; Uitterlinden, Andre G.; van den Boogaard, Malou; van Duijn, Cornelia M.; van Gilst, Wiek H.; Viikari, Jorma S.; Visscher, Peter M.; Vitart, Veronique; Voelker, Uwe; Waldenberger, Melanie; Weichenberger, Christian X.; Westra, Harm-Jan; Wijmenga, Cisca; Wolffenbuttel, Bruce H.; Yang, Jian; Bezzina, Connie R.; Munroe, Patricia B.; Snieder, Harold; Wright, Alan F.; Rudan, Igor; Boyer, Laurie A.; Asselbergs, Folkert W.; van Veldhuisen, Dirk J.; Stricker, Bruno H.; Psaty, Bruce M.; Ciullo, Marina; Sanna, Serena; Lehtimaki, Terho; Wilson, James F.; Bandinelli, Stefania; Alonso, Alvaro; Gasparini, Paolo; Jukema, J. Wouter; Kaeaeb, Stefan; Gudnason, Vilmundur; Felix, Stephan B.; Heckbert, Susan R.; de Boer, Rudolf A.; Newton-Cheh, Christopher; Hicks, Andrew A.; Chambers, John C.; Jamshidi, Yalda; Visel, Axel; Christoffels, Vincent M.; Isaacs, Aaron; Samani, Nilesh J.; de Bakker, Paul I. W./titolo:52 Genetic Loci Influencing Myocardial Mass/doi:10.1016%2Fj.jacc.2016.07.729/rivista:Journal of the American College of Cardiology (Print)/anno:2016/pagina_da:1435/pagina_a:1448/intervallo_pagine:1435–1448/volume:68, Journal of the American College of Cardiology, 68(13), 1435-1448, van der Harst, P, van Setten, J, Verweij, N, Vogler, G, Franke, L, Maurano, M T, Wang, X, Mateo Leach, I, Eijgelsheim, M, Sotoodehnia, N, Hayward, C, Sorice, R, Meirelles, O, Lyytikäinen, L-P, Polašek, O, Tanaka, T, Arking, D E, Ulivi, S, Trompet, S, Müller-Nurasyid, M, Smith, A V, Dörr, M, Kerr, K F, Magnani, J W, Del Greco M, F, Zhang, W, Nolte, I M, Silva, C T, Padmanabhan, S, Tragante, V, Esko, T, Abecasis, G R, Adriaens, M E, Andersen, K, Barnett, P, Bis, J C, Bodmer, R, Buckley, B M, Campbell, H, Cannon, M V, Chakravarti, A, Chen, L Y, Delitala, A, Devereux, R B, Doevendans, P A, Dominiczak, A F, Ferrucci, L, Ford, I, Gieger, C, Harris, T B, Haugen, E, Heinig, M, Hernandez, D G, Hillege, H L, Hirschhorn, J N, Hofman, A, Hubner, N, Hwang, S-J, Iorio, A, Kähönen, M, Kellis, M, Kolcic, I, Kooner, I K, Kooner, J S, Kors, J A, Lakatta, E G, Lage, K, Launer, L J, Levy, D, Lundby, A, Macfarlane, P W, May, D, Meitinger, T, Metspalu, A, Nappo, S, Naitza, S, Neph, S, Nord, A S, Nutile, T, Okin, P M, Olsen, J V, Oostra, B A, Penninger, J M, Pennacchio, L A, Pers, T H, Perz, S, Peters, A, Pinto, Y M, Pfeufer, A, Pilia, M G, Pramstaller, P P, Prins, B P, Raitakari, O T, Raychaudhuri, S, Rice, K M, Rossin, E J, Rotter, J I, Schafer, S, Schlessinger, D, Schmidt, C O, Sehmi, J, Silljé, H H W, Sinagra, G, Sinner, M F, Slowikowski, K, Soliman, E Z, Spector, T D, Spiering, W, Stamatoyannopoulos, J A, Stolk, R P, Strauch, K, Tan, S-T, Tarasov, K V, Trinh, B, Uitterlinden, A G, van den Boogaard, M, van Duijn, C M, van Gilst, W H, Viikari, J S, Visscher, P M, Vitart, V, Völker, U, Waldenberger, M, Weichenberger, C X, Westra, H-J, Wijmenga, C, Wolffenbuttel, B H, Yang, J, Bezzina, C R, Munroe, P B, Snieder, H, Wright, A F, Rudan, I, Boyer, L A, Asselbergs, F W, van Veldhuisen, D J, Stricker, B H, Psaty, B M, Ciullo, M, Sanna, S, Lehtimäki, T, Wilson, J F, Bandinelli, S, Alonso, A, Gasparini, P, Jukema, J W, Kääb, S, Gudnason, V, Felix, S B, Heckbert, S R, de Boer, R A, Newton-Cheh, C, Hicks, A A, Chambers, J C, Jamshidi, Y, Visel, A, Christoffels, V M, Isaacs, A, Samani, N J & de Bakker, P I W 2016, ' 52 Genetic Loci Influencing Myocardial Mass ', Journal of the American College of Cardiology, vol. 68, no. 13, pp. 1435-48 . https://doi.org/10.1016/j.jacc.2016.07.729, Journal of the American College of Cardiology, 68(13), 1435-1448. Elsevier USA, Journal of the American College of Cardiology, 68(13), 1435-1448. Elsevier Inc., Journal of the American College of Cardiology, 68(13), 1435-1448. ELSEVIER SCIENCE INC, J. Am. Coll. Cardiol. 68, 1435-1448 (2016), van der Harst, P, van Setten, J, Verweij, N, Vogler, G, Franke, L, Maurano, M T, Wang, X, Mateo Leach, I, Eijgelsheim, M, Sotoodehnia, N, Hayward, C, Sorice, R, Meirelles, O, Lyytikäinen, L-P, Polasek, O, Tanaka, T, Arking, D E, Ulivi, S, Trompet, S, Müller-Nurasyid, M, Smith, A V, Dörr, M, Kerr, K F, Magnani, J W, Del Greco M, F, Zhang, W, Nolte, I M, Silva, C T, Padmanabhan, S, Tragante, V, Esko, T, Abecasis, G R, Adriaens, M E, Andersen, K, Barnett, P, Bis, J C, Bodmer, R, Buckley, B M, Campbell, H, Cannon, M V, Chakravarti, A, Chen, L Y, Delitala, A, Devereux, R B, Doevendans, P A, Dominiczak, A F, Ferrucci, L, Ford, I, Gieger, C, Harris, T B, Haugen, E, Heinig, M, Hernandez, D G, Hillege, H L, Hirschhorn, J N, Hofman, A, Hubner, N, Hwang, S-J, Iorio, A, Kähönen, M, Kellis, M, Kolcic, I, Kooner, I K, Kooner, J S, Kors, J A, Lakatta, E G, Lage, K, Launer, L J, Levy, D, Lundby, A, Macfarlane, P W, May, D, Meitinger, T, Metspalu, A, Nappo, S, Naitza, S, Neph, S, Nord, A S, Nutile, T, Okin, P M, Olsen, J V, Oostra, B A, Penninger, J M, Pennacchio, L A, Pers, T H, Perz, S, Peters, A, Pinto, Y M, Pfeufer, A, Pilia, M G, Pramstaller, P P, Prins, B P, Raitakari, O T, Raychaudhuri, S, Rice, K M, Rossin, E J, Rotter, J I, Schafer, S, Schlessinger, D, Schmidt, C O, Sehmi, J, Silljé, H H W, Sinagra, G, Sinner, M F, Slowikowski, K, Soliman, E Z, Spector, T D, Spiering, W, Stamatoyannopoulos, J A, Stolk, R P, Strauch, K, Tan, S-T, Tarasov, K V, Trinh, B, Uitterlinden, A G, van den Boogaard, M, van Duijn, C M, van Gilst, W H, Viikari, J S, Visscher, P M, Vitart, V, Völker, U, Waldenberger, M, Weichenberger, C X, Westra, H-J, Wijmenga, C, Wolffenbuttel, B H, Yang, J, Bezzina, C R, Munroe, P B, Snieder, H, Wright, A F, Rudan, I, Boyer, L A, Asselbergs, F W, van Veldhuisen, D J, Stricker, B H, Psaty, B M, Ciullo, M, Sanna, S, Lehtimäki, T, Wilson, J F, Bandinelli, S, Alonso, A, Gasparini, P, Jukema, J W, Kääb, S, Gudnason, V, Felix, S B, Heckbert, S R, de Boer, R A, Newton-Cheh, C, Hicks, A A, Chambers, J C, Jamshidi, Y, Visel, A, Christoffels, V M, Isaacs, A, Samani, N J & de Bakker, P I W 2016, ' 52 Genetic Loci Influencing Myocardial Mass ', Journal of the American College of Cardiology, vol. 68, no. 13, pp. 1435-48 . https://doi.org/10.1016/j.jacc.2016.07.729, Repositorio EdocUR-U. Rosario, Universidad del Rosario, instacron:Universidad del Rosario
- Publication Year :
- 2016
-
Abstract
- BACKGROUND Myocardial mass is a key determinant of cardiac muscle function and hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the amplitude and duration of the QRS complex on the electrocardiogram (ECG). Abnormal QRS amplitude or duration reflect changes in myocardial mass and conduction, and are associated with increased risk of heart failure and death.OBJECTIVES This meta-analysis sought to gain insights into the genetic determinants of myocardial mass.METHODS We carried out a genome-wide association meta-analysis of 4 QRS traits in up to 73,518 individuals of European ancestry, followed by extensive biological and functional assessment.RESULTS We identified 52 genomic loci, of which 32 are novel, that are reliably associated with 1 or more QRS phenotypes at p CONCLUSIONS Taken together, our findings provide new insights into genes and biological pathways controlling myocardial mass and may help identify novel therapeutic targets. (C) 2016 by the American College of Cardiology Foundation.
- Subjects :
- 0301 basic medicine
Biological functions
Qrs
Electrocardiogram
Genetic Association Study
Heart Failure
Left Ventricular Hypertrophy
Candidate gene
Cardiac & Cardiovascular Systems
heart failure
Genome-wide association study
ELECTROCARDIOGRAM
030204 cardiovascular system & hematology
SCN5A gene
Gene locus
DISEASE
Muscle hypertrophy
In vivo study
0302 clinical medicine
Sodium channel Nav1.5
REGULATORY DNA
Sodium channel Nav1.8
Cardiac muscle
CARDIAC-HYPERTROPHY
Priority journal
RISK
Genetics
Validation study
Heart
Genetic parameters
Reliability
Chromatin
left ventricular hypertrophy
GENOME
Drosophila melanogaster
Phenotype
medicine.anatomical_structure
1117 Public Health And Health Services
genetic association study
Cardiology
cardiovascular system
HEART
Functional assessment
Histone modification
Cardiology and Cardiovascular Medicine
Genetic trait
Life Sciences & Biomedicine
Human
medicine.medical_specialty
Cardiomegaly
Locus (genetics)
Major clinical study
electrocardiogram
European
QRS
1102 Cardiovascular Medicine And Haematology
Article
03 medical and health sciences
QRS complex
LEFT-VENTRICULAR HYPERTROPHY
Internal medicine
Journal Article
medicine
Mus musculus
Protein binding
Animals
Humans
SCN10A gene
VOLTAGE
Cardiovascular parameters
Heart ventricle hypertrophy
Science & Technology
Human genome
Animal
business.industry
MORTALITY
In vitro study
ta3121
medicine.disease
DYSFUNCTION
030104 developmental biology
Gene identification
Cardiovascular System & Hematology
Genetic Loci
Heart failure
Expression quantitative trait loci
Genetic association
Meta analysis (topic)
Cardiovascular System & Cardiology
Genetic variability
Transcription factor
Myocardial mass
business
Subjects
Details
- Language :
- English
- ISSN :
- 07351097
- Volume :
- 68
- Issue :
- 13
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Cardiology
- Accession number :
- edsair.doi.dedup.....5db2fc7f0a4c18983fe62e1ec6c7ffd5