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Evidence of a cross-protective immune response to influenza A in the cotton rat model
Evidence of a cross-protective immune response to influenza A in the cotton rat model
- Source :
- Vaccine. 24(37-39)
- Publication Year :
- 2006
-
Abstract
- Epidemiologic evidence suggests that cross-protective immune responses to influenza A viruses that have different hemagglutinin and neuraminidase subtypes occur in humans. This study characterized this heterosubtypic immunity in cotton rats (Sigmodon hispidus). Animals were infected with influenza A/PR/8/34 (H1N1) or A/Wuhan/359/95 (H3N2), and then challenged with A/Wuhan/359/95(H3N2) virus 4 weeks later. Viral titers, respiratory rates, and pathology of the respiratory tract following primary and secondary infection were compared. Cross-protection from heterosubtypic influenza A challenge in cotton rats was characterized by enhanced viral clearance, protection from tachypnea, a vigorous early cellular recall response, and a reduction in bronchiolar epithelial cell damage. Cross-protection was retained in steroid treated animals, in which the inflammatory recall response was minimal. Identification of the mechanisms that contribute to cross-protection in cotton rats may lead to the development of influenza vaccine strategies that are broadly protective.
- Subjects :
- Lung Diseases
Male
Influenza vaccine
Secondary infection
Hemagglutinin (influenza)
Virus Replication
Virus
Immune system
Influenza A Virus, H1N1 Subtype
Orthomyxoviridae Infections
Animals
Cotton rat
Sigmodontinae
Heterosubtypic immunity
General Veterinary
General Immunology and Microbiology
biology
Influenza A Virus, H3N2 Subtype
Public Health, Environmental and Occupational Health
biology.organism_classification
Virology
Rats
Infectious Diseases
Influenza Vaccines
Immunology
biology.protein
Molecular Medicine
Female
Immunization
Neuraminidase
Subjects
Details
- ISSN :
- 0264410X
- Volume :
- 24
- Issue :
- 37-39
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....5dbc7149a2f87f75584ffe1a9cd3e959