Back to Search
Start Over
Variable Association of Reactive Intermediate Genes with Systemic Lupus Erythematosus in Populations with Different African Ancestry
- Source :
- The Journal of rheumatology, vol 40, iss 6
- Publication Year :
- 2013
- Publisher :
- The Journal of Rheumatology, 2013.
-
Abstract
- Objective.Little is known about the genetic etiology of systemic lupus erythematosus (SLE) in individuals of African ancestry, despite its higher prevalence and greater disease severity. Overproduction of nitric oxide (NO) and reactive oxygen species are implicated in the pathogenesis and severity of SLE, making NO synthases and other reactive intermediate-related genes biological candidates for disease susceptibility. We analyzed variation in reactive intermediate genes for association with SLE in 2 populations with African ancestry.Methods.A total of 244 single-nucleotide polymorphisms (SNP) from 53 regions were analyzed in non-Gullah African Americans (AA; 1432 cases and 1687 controls) and the genetically more homogeneous Gullah of the Sea Islands of South Carolina (133 cases and 112 controls). Single-marker, haplotype, and 2-locus interaction tests were computed for these populations.Results.The glutathione reductase geneGSR(rs2253409; p = 0.0014, OR 1.26, 95% CI 1.09–1.44) was the most significant single SNP association in AA. In the Gullah, the NADH dehydrogenaseNDUFS4(rs381575; p = 0.0065, OR 2.10, 95% CI 1.23–3.59) and NO synthase geneNOS1(rs561712; p = 0.0072, OR 0.62, 95% CI 0.44–0.88) were most strongly associated with SLE. When both populations were analyzed together,GSRremained the most significant effect (rs2253409; p = 0.00072, OR 1.26, 95% CI 1.10–1.44). Haplotype and 2-locus interaction analyses also uncovered different loci in each population.Conclusion.These results suggest distinct patterns of association with SLE in African-derived populations; specific loci may be more strongly associated within select population groups.
- Subjects :
- SINGLE-NUCLEOTIDE POLYMORPHISM
Nitric Oxide Synthase Type I
Pathogenesis
Genotype
Lupus Erythematosus, Systemic
2.1 Biological and endogenous factors
Immunology and Allergy
Aetiology
Genetics
education.field_of_study
Single Nucleotide
Glutathione Reductase
Public Health and Health Services
Adult
NOS1
Clinical Sciences
Immunology
Population
Black People
AFRICAN AMERICANS
Lupus
Single-nucleotide polymorphism
Biology
Polymorphism, Single Nucleotide
Autoimmune Disease
Article
Rheumatology
Clinical Research
Humans
SNP
Genetic Predisposition to Disease
Polymorphism
Allele
education
Alleles
Genetic Association Studies
Electron Transport Complex I
Lupus Erythematosus
Inflammatory and immune system
Systemic
Haplotype
NADH Dehydrogenase
Arthritis & Rheumatology
OXYGEN COMPOUNDS
SYSTEMIC LUPUS ERYTHEMATOSUS
Haplotypes
Genetic Loci
Subjects
Details
- ISSN :
- 14992752 and 0315162X
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- The Journal of Rheumatology
- Accession number :
- edsair.doi.dedup.....5dbd488d726fff956c6884adc36e31d2
- Full Text :
- https://doi.org/10.3899/jrheum.120989