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Carriage of GB virus C/hepatitis G virus RNA is associated with a slower immunologic, virologic, and clinical progression of human immunodeficiency virus disease in coinfected persons
- Source :
- The Journal of infectious diseases. 179(4)
- Publication Year :
- 1999
-
Abstract
- The prevalence of GB virus C (GBV-C) infection is high in human immunodeficiency virus (HIV)-infected persons. However, the long-term consequences of coinfection are unknown. HIV-positive persons with a well-defined duration of infection were screened on the basis of their GBV-C/hepatitis G virus (HGV) RNA status and studied. GBV-C/HGV viremia was observed in 23, who carried the virus over a mean of 7.7 years. All parameters (survival, CDC stage B/C, HIV RNA load, CD4 T cell count) showed significant differences in terms of the cumulative progression rate between persons positive and negative for GBV-C/HGV RNA. When GBV-C/HGV RNA-positive and -unexposed subjects were matched by age, sex, baseline HIV RNA load, and baseline CD4 T cell count, HIV disease progression appeared worse in GBV-C/HGV RNA-negative subjects. The carriage of GBV-C/HGV RNA is associated with a slower progression of HIV disease in coinfected persons.
- Subjects :
- Adult
Male
Hepatitis, Viral, Human
HIV Infections
Virus Replication
Virus
Flaviviridae
Acquired immunodeficiency syndrome (AIDS)
medicine
Immunology and Allergy
Humans
Hepatitis
biology
business.industry
virus diseases
Middle Aged
biology.organism_classification
medicine.disease
GB virus C
Virology
digestive system diseases
CD4 Lymphocyte Count
Infectious Diseases
Immunology
Carrier State
Coinfection
RNA, Viral
Female
Viral disease
business
Viral load
Subjects
Details
- ISSN :
- 00221899
- Volume :
- 179
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The Journal of infectious diseases
- Accession number :
- edsair.doi.dedup.....5dbe774231bcff0c409f5f4f8f337f88