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Expression Analysis of SPARC/Osteonectin in Oral Squamous Cell Carcinoma Patients: From Saliva to Surgical Specimen
- Source :
- BioMed Research International, BioMed Research International, Vol 2013 (2013)
- Publication Year :
- 2013
- Publisher :
- Hindawi Limited, 2013.
-
Abstract
- Oral squamous cell carcinoma (OSCC) remains a significant cause of morbidity and mortality, with approximately 540,000 new cases annually worldwide. The molecular mechanisms related to the pathogenesis of this disease are still poorly understood. The discovery of a molecular marker that allows the early detection of this cancer, which can be easily identified in biological samples, such as saliva, without intervening in advanced stages, is a challenge. Numerous studies have identified a panel of molecular markers differently expressed in OSCC and normal oral mucosa. In particular, it was found an aberrant expression of matricellular glycoprotein SPARC. SPARC is involved in normal tissue remodeling, regulating the deposition of extracellular matrix, but also in neoplastic transformation. In fact, aberrant SPARC expression was detected both in stromal cells associated with cancer and in tumor cells. The aim of our study was the evaluation of SPARC on a retrospective series of 119 OSCC cases and the validation of the obtained data on a prospective series of 27 patients with OSCC, of whom we have previously collected saliva, and smeared material. The obtained results were correlated with each other and with clinical pathological parameters at our disposal. The study demonstrated a prognostic value of SPARC, especially with regard to its expression in the stroma surrounding OSCC (P< 0.05).
- Subjects :
- Adult
Male
Salivary Proteins and Peptide
Saliva
Pathology
medicine.medical_specialty
Stromal cell
Article Subject
Immunology and Microbiology (all)
lcsh:Medicine
General Biochemistry, Genetics and Molecular Biology
Neoplasm Protein
Pathogenesis
Stroma
Retrospective Studie
medicine
Humans
Osteonectin
Neoplastic transformation
Salivary Proteins and Peptides
Retrospective Studies
Aged
Aged, 80 and over
Mouth neoplasm
Biochemistry, Genetics and Molecular Biology (all)
General Immunology and Microbiology
biology
lcsh:R
Cancer
General Medicine
Middle Aged
medicine.disease
Mouth Neoplasm
Neoplasm Proteins
Gene Expression Regulation, Neoplastic
stomatognathic diseases
Carcinoma, Squamous Cell
biology.protein
Mouth Neoplasms
Female
Research Article
Human
Subjects
Details
- ISSN :
- 23146141 and 23146133
- Volume :
- 2013
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....5dc527099ee8d88ec464c406d7cdd00a
- Full Text :
- https://doi.org/10.1155/2013/736438